Ayesha P. Ng

TL;DR: This article performed single-cell characterization of the human cerebrovasculature using both ex vivo fresh tissue experimental enrichment and post mortem in silico sorting of human cortical tissue samples.

TL;DR: In this article , a single-cell transcriptomics profiling of post-mortem human brains from APOE4 carriers compared with non-carriers was performed to gain more comprehensive insights into the impact of APOE-4 on the human brain.

TL;DR: It is shown that APOE4-genotype associated differences are significantly enriched among AD-associated genes in capillary and venule endothelial cells, and subsets of pericytes and fibroblasts, which underlie the vascular dysregulation in APoe4-associated cognitive decline.

TL;DR: Huang et al. as mentioned in this paper used single-cell RNA sequencing of postmortem brain sections of mouse mammillary body and brain slice electrophysiology to show that lateral MB neurons of 5xFAD mice harbored aberrant hyperactivity that correlated with impaired memory in two behavioral tests.