A
Audrey H. Lau
Publications - 9
Citations - 729
Audrey H. Lau is an academic researcher. The author has contributed to research in topics: Tenofovir alafenamide & HBsAg. The author has an hindex of 6, co-authored 9 publications receiving 460 citations.
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Journal ArticleDOI
96 weeks treatment of tenofovir alafenamide vs. tenofovir disoproxil fumarate for hepatitis B virus infection
Kosh Agarwal,Maurizia Rossana Brunetto,Wai-Kay Seto,Young-Suk Lim,Scott Fung,Patrick Marcellin,Sang Hoon Ahn,Namiki Izumi,Wan-Long Chuang,Ho Bae,Manoj Sharma,Harry L.A. Janssen,Harry L.A. Janssen,Calvin Q. Pan,Mustafa Kemal Çelen,Norihiro Furusyo,Shalimar,Ki Tae Yoon,Huy N. Trinh,John F. Flaherty,Anuj Gaggar,Audrey H. Lau,Andrea L. Cathcart,Lanjia Lin,Neeru Bhardwaj,Vithika Suri,G. Mani Subramanian,Edward Gane,Maria Buti,Henry Lik-Yuen Chan +29 more
TL;DR: In patients with HBV infection, TAF remained as effective as TDF, with continued improved renal and bone safety, two years after the initiation of treatment.
Journal ArticleDOI
Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis B.
Harry L.A. Janssen,Maurizia Rossana Brunetto,Yoon Jun Kim,Carlo Ferrari,Benedetta Massetto,Anh Hoa Nguyen,Adarsh Joshi,Jacky Woo,Audrey H. Lau,Anuj Gaggar,G. Mani Subramanian,Eric M. Yoshida,Sang Hoon Ahn,Naoky Tsai,Scott Fung,Edward Gane +15 more
TL;DR: Vesatolimod was safe and well-tolerated in patients with CHB, demonstrating consistent dose-dependent pharmacodynamic induction of ISG15 without significant systemic induction of IFNα expression or related symptoms.
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TLR7 Agonist Increases Responses of Hepatitis B Virus-Specific T Cells and Natural Killer Cells in Patients With Chronic Hepatitis B Treated With Nucleos(T)Ide Analogues.
Carolina Boni,Andrea Vecchi,Marzia Rossi,Diletta Laccabue,Tiziana Giuberti,Arianna Alfieri,Pietro Lampertico,Glenda Grossi,Floriana Facchetti,Maurizia Rossana Brunetto,Barbara Coco,Daniela Cavallone,Alessandra Mangia,Rosanna Santoro,Valeria Piazzolla,Audrey H. Lau,Anuj Gaggar,G. Mani Subramanian,Carlo Ferrari +18 more
TL;DR: Twelve weeks administration of GS-9620 had no significant effect on serum hepatitis B surface antigen levels, but did appear to increase T-cell and NK-cell responses and reduce the ability of NK to suppress T cells.
Journal ArticleDOI
Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in virologically suppressed patients with chronic hepatitis B: a randomised, double-blind, phase 3, multicentre non-inferiority study
Pietro Lampertico,Maria Buti,Scott Fung,Sang Hoon Ahn,Wan-Long Chuang,Won Young Tak,Alnoor Ramji,Chi Yi Chen,Edward Tam,Ho Bae,Xiaoli Ma,John F. Flaherty,Anuj Gaggar,Audrey H. Lau,Yang Liu,George Wu,Vithika Suri,Susanna K. Tan,G. Mani Subramanian,Huy N. Trinh,Seung Kew Yoon,Kosh Agarwal,Young-Suk Lim,Henry Lik-Yuen Chan +23 more
TL;DR: A randomised, multicentre, double-blind, phase 3 non-inferiority study to evaluate the efficacy and safety of tenofovir alafenamide in patients with HBV infection switching from ten ofovir disoproxil fumarate who are virally suppressed.
Journal ArticleDOI
Combined GS-4774 and Tenofovir Therapy Can Improve HBV-Specific T-Cell Responses in Patients With Chronic Hepatitis
Carolina Boni,Harry L.A. Janssen,Marzia Rossi,Seung Kew Yoon,Andrea Vecchi,Valeria Barili,Eric M. Yoshida,Huy N. Trinh,Timothy C. Rodell,Diletta Laccabue,Arianna Alfieri,Federica Brillo,Paola Fisicaro,Greta Acerbi,Giuseppe Pedrazzi,Pietro Andreone,Carmela Cursaro,Marzia Margotti,Rosanna Santoro,Valeria Piazzolla,Maurizia Rossana Brunetto,Barbara Coco,Daniela Cavallone,Yang Zhao,Adarsh Joshi,Jacky Woo,Audrey H. Lau,Anuj Gaggar,G. Mani Subramanian,Benedetta Massetto,Scott Fung,Sang Hoon Ahn,Xiaoli Ma,Alessandra Mangia,Carlo Ferrari +34 more
TL;DR: For example, GS-4774, a yeast-based therapeutic vaccine engineered to express HBV antigens, given with tenofovir disoproxil fumarate (TDF) to untreated patients with chronic hepatitis B virus infection was evaluated in a multicenter phase 2 study as mentioned in this paper.