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Audrey McAlinden
Researcher at Washington University in St. Louis
Publications - 58
Citations - 1763
Audrey McAlinden is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Alternative splicing & Exon. The author has an hindex of 22, co-authored 54 publications receiving 1456 citations. Previous affiliations of Audrey McAlinden include Shriners Hospitals for Children & Edinburgh Napier University.
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Mechanisms of Disease: role of chondrocytes in the pathogenesis of osteoarthritis—structure, chaos and senescence
TL;DR: Evidence suggests that cell aging is important in the pathogenesis of osteoarthritis, and anti-aging strategies might complement existing therapeutic targets related to anabolism, catabolicism, inflammation, and apoptosis—processes that are integral to the pathogenic of osteOarthritis.
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Inflammation and epigenetic regulation in osteoarthritis.
TL;DR: Information on inflammatory pathways in arthritis is provided and published research on how epigenetic regulators are affected by inflammation in chondrocytes is summarized to discuss how altered expression of some of these epigenetic factors can induce either catabolic or anti-catabolic effects in response to inflammatory signals.
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Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice.
Sheri L. Bonar,Susannah Brydges,James L. Mueller,Matthew D. McGeough,Carla A. Peña,Debbie K. Chen,Susan K. Grimston,Cynthia L. Hickman-Brecks,Soumya Ravindran,Audrey McAlinden,Deborah V. Novack,Daniel L. Kastner,Roberto Civitelli,Hal M. Hoffman,Gabriel Mbalaviele +14 more
TL;DR: Findings provide direct evidence linking a NOMID-associated NLRP3-activating mutation to abnormalities of postnatal skeletal growth and bone remodeling.
Journal ArticleDOI
α-Helical Coiled-coil Oligomerization Domains Are Almost Ubiquitous in the Collagen Superfamily
Audrey McAlinden,Thomasin A. Smith,Linda J. Sandell,Damien Ficheux,David A.D. Parry,David J.S. Hulmes +5 more
TL;DR: It is shown that most members of the collagen superfamily contain short, repeating heptad sequences typical of coiled coils, which suggest that coiled-coil oligomerization domains are widely used in the assembly of collagens and collagen-like proteins.
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Emerging roles for long noncoding RNAs in skeletal biology and disease.
TL;DR: The likely utility of lncRNAs as biomarkers and therapeutic targets for diseases of the skeletal system, including osteoarthritis, osteoporosis, and in cancers ofThe skeletal system are addressed.