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Audrey R. Tyrka
Researcher at Brown University
Publications - 144
Citations - 10798
Audrey R. Tyrka is an academic researcher from Brown University. The author has contributed to research in topics: Major depressive disorder & Child abuse. The author has an hindex of 50, co-authored 135 publications receiving 9332 citations. Previous affiliations of Audrey R. Tyrka include NewYork–Presbyterian Hospital & Butler Hospital.
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Journal ArticleDOI
Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression
Donald A. Malone,Darin D. Dougherty,Ali R. Rezai,Linda L. Carpenter,Gerhard Friehs,Emad N. Eskandar,Scott L. Rauch,Steven A. Rasmussen,Andre G. Machado,Cynthia S. Kubu,Audrey R. Tyrka,Lawrence H. Price,Paul H. Stypulkowski,Jonathon E. Giftakis,Mark T. Rise,Paul Malloy,Stephen Salloway,Benjamin D. Greenberg +17 more
TL;DR: Deep brain stimulation of the VC/VS offers promise for the treatment of refractory major depression.
Journal ArticleDOI
Decreased Adrenocorticotropic Hormone and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment
Linda L. Carpenter,John P. Carvalho,Audrey R. Tyrka,Audrey R. Tyrka,Lauren M. Wier,Andrea Feijo Mello,Marcelo Feijó de Mello,George M. Anderson,Charles W. Wilkinson,Lawrence H. Price,Lawrence H. Price +10 more
TL;DR: In adults without diagnosable psychopathology, childhood maltreatment is associated with diminished HPA axis response to a psychosocial stressor.
Journal ArticleDOI
Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults.
Audrey R. Tyrka,Audrey R. Tyrka,Lawrence H. Price,Lawrence H. Price,Carmen J. Marsit,Oakland C. Walters,Linda L. Carpenter,Linda L. Carpenter +7 more
TL;DR: Findings suggest that childhood maltreatment or adversity may lead to epigenetic modifications of the human GR gene, which could underlie the associations between childhood adversity, alterations in stress reactivity, and risk for psychopathology.
Journal ArticleDOI
Association between Plasma IL-6 Response to Acute Stress and Early-Life Adversity in Healthy Adults
Linda L. Carpenter,Linda L. Carpenter,Cyrena E. Gawuga,Audrey R. Tyrka,Audrey R. Tyrka,Janet K. Lee,George M. Anderson,Lawrence H. Price,Lawrence H. Price +8 more
TL;DR: Plasma IL-6 response to the Trier Social Stress Test (TSST) was examined in 69 healthy adult subjects without depression or post-traumatic stress disorder to further elucidate the relationship between childhood maltreatment and pro-inflammatory cytokine production.
Journal ArticleDOI
A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression
Darin D. Dougherty,Ali R. Rezai,Linda L. Carpenter,Robert H Howland,Mahendra T. Bhati,John P. O'Reardon,Emad N. Eskandar,Gordon H. Baltuch,Andre D. Machado,Douglas Kondziolka,Cristina Cusin,Karleyton C. Evans,Lawrence H. Price,Karen Jacobs,Mayur Pandya,Timothey Denko,Audrey R. Tyrka,Tim Brelje,Thilo Deckersbach,Cynthia S. Kubu,Donald A. Malone +20 more
TL;DR: The results of this first randomized controlled study of DBS for the treatment of TRD did not demonstrate a significant difference in response rates between the active and control groups at the end of the 16-week controlled phase.