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Audrey Robinson-White
Researcher at National Institutes of Health
Publications - 18
Citations - 1364
Audrey Robinson-White is an academic researcher from National Institutes of Health. The author has contributed to research in topics: PRKAR1A & Protein kinase A. The author has an hindex of 14, co-authored 18 publications receiving 1284 citations. Previous affiliations of Audrey Robinson-White include University of Düsseldorf.
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Journal ArticleDOI
A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia.
Anelia Horvath,Sosipatros Boikos,Christoforos Giatzakis,Audrey Robinson-White,Lionel Groussin,Kurt J. Griffin,Erica V. Stein,Elizabeth Levine,Georgia Delimpasi,Hui Pin Hsiao,Meg Keil,Sarah L. Heyerdahl,Ludmila Matyakhina,Rossella Libé,Amato Fratticci,Lawrence S. Kirschner,Kevin Cramer,Rolf C. Gaillard,Xavier Bertagna,J. Aidan Carney,Jérôme Bertherat,Ioannis Bossis,Constantine A. Stratakis +22 more
TL;DR: Tumor tissues showed 2q31–2q35 LOH, decreased protein expression and high cyclic nucleotide levels and cAMP-responsive element binding protein (CREB) phosphorylation, suggesting another means by which dysregulation of cAMP signaling causes endocrine tumors.
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Clinical and Genetic Heterogeneity, Overlap with Other Tumor Syndromes, and Atypical Glucocorticoid Hormone Secretion in Adrenocorticotropin-Independent Macronodular Adrenal Hyperplasia Compared with Other Adrenocortical Tumors
Hui-Pin Hsiao,Lawrence S. Kirschner,Isabelle Bourdeau,Margaret F. Keil,Sosipatros Boikos,Somya Verma,Audrey Robinson-White,Maria Nesterova,André Lacroix,Constantine A. Stratakis +9 more
TL;DR: AIMAH is a clinically and genetically heterogeneous disorder that can be associated with various genetic defects and aberrant hormone receptors; UFCs and other measures of adrenocortical activity can be misleadingly normal.
Journal ArticleDOI
A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions
Kurt J. Griffin,Lawrence S. Kirschner,Ludmila Matyakhina,Sotirios Stergiopoulos,Audrey Robinson-White,S M Lenherr,Frank Weinberg,E S Claflin,Dalia L. Batista,Isabelle Bourdeau,A Voutetakis,Fabiano Sandrini,Elise Meoli,Andrew J. Bauer,Yoon S. Cho-Chung,S R Bornstein,J A Carney,C. A. Stratakis +17 more
TL;DR: The tTA/X2AS mouse line with a downregulated Prkar1a gene replicates several of the findings in Carney complex patients and their affected tissues, supporting the role of RIα as a candidate tumour suppressor gene.
Journal ArticleDOI
Adrenal hyperplasia and adenomas are associated with inhibition of phosphodiesterase 11A in carriers of PDE11A sequence variants that are frequent in the population.
Anelia Horvath,Christoforos Giatzakis,Audrey Robinson-White,Sosipatros Boikos,Elizabeth Levine,Kurt J. Griffin,Erica V. Stein,Virginia Kamvissi,Payal D. Soni,Ioannis Bossis,Wouter W. de Herder,J. Aidan Carney,Jérôme Bertherat,Peter K. Gregersen,Elaine F. Remmers,Constantine A. Stratakis +15 more
TL;DR: It is concluded that missense mutations of the PDE11A gene that affect enzymatic activity in vitro are present in the general population and may also contribute to a predisposition to other tumors, in addition to their association with adrenocortical hyperplasia.
Journal ArticleDOI
Down-Regulation of Regulatory Subunit Type 1A of Protein Kinase A Leads to Endocrine and Other Tumors
Kurt J. Griffin,Lawrence S. Kirschner,Ludmila Matyakhina,Sotirios Stergiopoulos,Audrey Robinson-White,Sara M. Lenherr,Frank Weinberg,Edward Claflin,Elise Meoli,Yoon S. Cho-Chung,Constantine A. Stratakis +10 more
TL;DR: This mouse provides a novel, useful tool for the investigation of cyclic AMP, RIα, and PKA functions and confirms the critical role of Prkar1a in tumorigenesis in endocrine and other tissues.