Dr. C. Ge, Prof. K.-J. Jin, Prof. L. Gu, L.-C. Peng, Prof. Y.-S. Hu, Dr. H.-Z. Guo, Dr. H.-F. Shi, J.-K. Li, Prof. C. Wang, M. He, Prof. H.-B. Lu, Prof. G.-Z. Yang Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 , China E-mail: gechen@iphy.ac.cn; kjjin@iphy.ac.cn; l.gu@iphy.ac.cn Prof. K.-J. Jin, Prof. L. Gu, Prof. G.-Z. Yang Collaborative Innovation Center of Quantum Matter Beijing 100190 , China Dr. J.-O. Wang Beijing Synchrotron Radiation Facility Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 , China Prof. X.-X. Guo State Key Laboratory of High Performance Ceramics and Superfi ne Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 , China

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Metal–Insulator Transition Induced by Oxygen Vacancies from Electrochemical Reaction in Ionic Liquid-Gated Manganite Films

Gating-induced reversible HxVO2 phase transformations for neuromorphic computing

The aim of this review is to comprehensively summarize the recent achievements in the field of toxicogenomics and cancer research regarding genetic-environmental interactions in carcinogenesis and detection of genetic aberrations in cancer genomes by next-generation sequencing technology. Cancer is primarily a genetic disease in which genetic factors and environmental stimuli interact to cause genetic and epigenetic aberrations in human cells. Mutations in the germline act as either high-penetrance alleles that strongly increase the risk of cancer development, or as low-penetrance alleles that mildly change an individual's susceptibility to cancer. Somatic mutations, resulting from either DNA damage induced by exposure to environmental mutagens or from spontaneous errors in DNA replication or repair are involved in the development or progression of the cancer. Induced or spontaneous changes in the epigenome may also drive carcinogenesis. Advances in next-generation sequencing technology provide us opportu...

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Toxicogenomics and cancer susceptibility: advances with next-generation sequencing.

SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter.

Post-translational histone modifications such as acetylation and methylation can affect gene expression. Histone acetylation is commonly associated with activation of gene expression whereas histone methylation is linked to either activation or repression of gene expression. Depending on the site of histone modification, several histone marks can be present throughout the genome. A combination of these histone marks can shape global chromatin architecture, and changes in patterns of marks can affect the transcriptomic landscape. Alterations in several histone marks are associated with different types of cancers, and these alterations are distinct from marks found in original normal tissues. Therefore, it is hypothesized that patterns of histone marks can change during the process of tumorigenesis. This review focuses on histone methylation changes (both removal and addition of methyl groups) in malignant melanoma, a deadly skin cancer, and the implications of specific inhibitors of these modifications as a combinatorial therapeutic approach.

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Tackling malignant melanoma epigenetically: histone lysine methylation

The recent development of a semiconductor-based, non-optical DNA sequencing technology promises scalable, low-cost and rapid sequence data production. The technology has previously been applied mainly to genomic sequencing and targeted re-sequencing. Here we demonstrate the utility of Ion Torrent semiconductor-based sequencing for sensitive, efficient and rapid chromatin immunoprecipitation followed by sequencing (ChIP-seq) through the application of sample preparation methods that are optimized for ChIP-seq on the Ion Torrent platform. We leverage this method for epigenetic profiling of tumour tissues.

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Austin Tzou

Papers

Semiconductor-based DNA sequencing of histone modification states

Semiconductor-based DNA sequencing of histone modification states