Kunal Rai

TL;DR: This clinicopathological and multi-dimensional analysis suggests that the prognosis of melanoma patients with regional metastases is influenced by tumor stroma immunobiology, offering insights to further personalize therapeutic decision-making.

TL;DR: Using zebrafish embryos, evidence is provided for a coupled mechanism of 5-meC demethylation, whereby AID deaminates 5- meC, followed by thymine base excision by Mbd4, promoted by Gadd45.

TL;DR: It is shown that homozygous loss of APC causes failed intestinal cell differentiation but that this occurs in the absence of nuclear beta-catenin and increased intestinal cell proliferation, which suggests that, following APC loss, CtBP1 contributes to adenoma initiation as a first step, whereas KRAS activation and beta-Catenin nuclear localization promote adenomas progression to carcinomas as a second step.

TL;DR: It is shown that morpholino knockdown of Dnmt2 protein in zebrafish embryos confers differentiation defects in particular organs, including the retina, liver, and brain.

TL;DR: Findings reveal how control of βOHB-activated signaling in ISCs by diet helps to fine-tune stem cell adaptation in homeostasis and injury.