Christine S. Cheng

TL;DR: This work develops split-pool recognition of interactions by tag extension (SPRITE), a method that enables genome-wide detection of higher-order interactions within the nucleus and generates a global model whereby nuclear bodies act as inter-chromosomal hubs that shape the overall packaging of DNA in the nucleus.

TL;DR: A broad mechanistic framework for the transcriptional induction of mammalian primary response genes by Toll-like receptors and other stimuli is described, which includes CpG-island promoters, which facilitate promiscuous induction from constitutively active chromatin without a requirement for SWI/SNF nucleosome remodeling complexes.

TL;DR: An unexpected and general strategy that is based on the requirement for specific cohorts of inhibitory histone methyltransferases to impose gene-specific gatekeeper functions that prevent unliganded nuclear receptors and other classes of regulated transcription factors from binding to their target gene promoters and causing constitutive gene activation in the absence of stimulating signals is reported.

TL;DR: Chang et al. as mentioned in this paper developed a high-throughput Chromatin ImmunoPrecipitation (HT-ChIP) method to systematically map protein-DNA interactions to define the dynamics of DNA binding by 25 transcription factors and 4 chromatin marks at 4 time-points following pathogen stimulus of dendritic cells.

TL;DR: The dual PI3K-mTOR inhibitor PI-103 induces autophagy in a form of glioma that is resistant to therapy, and elicited cell death with combinations of drugs that are either now in use in patients or in clinical trials, raising the hope that this approach could be readily translatable to human therapy.