Following Sharpless' visionary characterization of several idealized reactions as click reactions, the materials science and synthetic chemistry communities have pursued numerous routes toward the identification and implementation of these click reactions. Herein, we review the radical-mediated thiol-ene reaction as one such click reaction. This reaction has all the desirable features of a click reaction, being highly efficient, simple to execute with no side products and proceeding rapidly to high yield. Further, the thiol-ene reaction is most frequently photoinitiated, particularly for photopolymerizations resulting in highly uniform polymer networks, promoting unique capabilities related to spatial and temporal control of the click reaction. The reaction mechanism and its implementation in various synthetic methodologies, biofunctionalization, surface and polymer modification, and polymerization are all reviewed.

Thiol–Ene Click Chemistry

The merits of thiol-click chemistry and its potential for making new forays into chemical synthesis and materials applications are described Since thiols react to high yields under benign conditions with a vast range of chemical species, their utility extends to a large number of applications in the chemical, biological, physical, materials and engineering fields This critical review provides insight into emerging venues for application as well as new mechanistic understanding of this exceptional chemistry in its many forms (81 references)

Thiol-click chemistry: a multifaceted toolbox for small molecule and polymer synthesis

Indoles in multicomponent processes (MCPs).

Metal-Free Multicomponent Syntheses of Pyridines

Arylglyoxals in synthesis of heterocyclic compounds.

Sulfonic acid functionalized silica as an efficient heterogeneous recyclable catalyst for one-pot synthesis of 2-substituted benziimidazoles

An efficient procedure for the synthesis of substituted pyridines using KF·Al2O3

Three component reaction of indoles, benzaldehydes, and N-alkylanilines in the presence of 2,4,6-trichloro-1,3,5-triazine (TCT) afforded the corresponding 3-[(N-alkylanilino)(aryl)methyl]indoles at room temperature in high yields (87-95%) within 1 to 2.5 hours.

Avula Satya Kumar

Papers

Sulfonic acid functionalized silica as an efficient heterogeneous recyclable catalyst for one-pot synthesis of 2-substituted benziimidazoles

An efficient procedure for the synthesis of substituted pyridines using KF·Al2O3

A Facile Synthesis of 3-[(N-Alkylanilino)(aryl)methyl]indolesUsing TCT

New bioactive macrocyclic diterpenoids from Jatropha multifida.

Efficient Thiocyanation of Indoles Using Para-Toluene Sulfonic Acid