Journal ArticleDOI
Sulfonic acid functionalized silica as an efficient heterogeneous recyclable catalyst for one-pot synthesis of 2-substituted benziimidazoles
TLDR
An efficient one-pot synthesis of 2-substituted benzimidazoles from o-phenylenediamine and aldehydes in the presence of sulfonic acid functionalized silica at room temperature is reported in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2008-09-01. It has received 27 citations till now. The article focuses on the topics: Sulfonic acid & One-pot synthesis.read more
Citations
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Journal ArticleDOI
Recyclizations of 3-formylchromones with binucleophiles
Andrey S. Plaskon,Andrey S. Plaskon,Oleksandr O. Grygorenko,Oleksandr O. Grygorenko,Sergey V. Ryabukhin +4 more
Journal ArticleDOI
Copper-catalyzed cascade synthesis of benzimidazoquinazoline derivatives under mild condition.
TL;DR: A convenient and efficient copper-catalyzed cascade method has been developed for the synthesis of benzimidazoquinazoline derivatives via reactions of readily available substituted 2-(2-halophenyl)benzoimidazoles with amidines or guanidine under mild conditions (even at room temperature).
Journal ArticleDOI
Silica functionalized propyl sulfonic acid (SiO2-Pr-SO3H): An efficient catalyst in organic reactions
TL;DR: In this article, the preparation and application of SiO 2 -Pr-SO 3 H in organic synthesis is investigated, and the results show that it can be removed easily, recovered and reused without significant loss of activity.
Journal ArticleDOI
Conventional and Microwave-Assisted Synthesis of Benzimidazole Derivatives and Their In Vitro Inhibition of Human Cyclooxygenase
Daniela Secci,Adriana Bolasco,Melissa D'Ascenzio,Flavio della Sala,Matilde Yáñez,Simone Carradori +5 more
TL;DR: In this paper, a large series of 1,2-diaryl-benzimidazole and 2-aryl-1H-Benzimidate derivatives were synthesized with slight differences using both microwave irradiation and conventional heating methods.
Journal ArticleDOI
Copper-catalyzed cascade synthesis of alkyl 6-aminobenzimidazo[2,1-a]isoquinoline-5-carboxylates.
TL;DR: The novel copper-catalyzed cascade method provides diverse and useful poly N-heterocyclic compounds for combinatorial chemistry and medicinal chemistry.
References
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Journal ArticleDOI
The combinatorial synthesis of bicyclic privileged structures or privileged substructures
TL;DR: Privileged substructures are believed to achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns.
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Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles.
T. Roth,M. L. Morningstar,Paul L. Boyer,Stephen H. Hughes,Robert W. Buckheit,Christopher J. Michejda +5 more
TL;DR: The activity of 35 against wild-type and resistant strains with amino acid substitution in RT is comparable to that of other nonnucleoside inhibitors currently undergoing clinical trials, most of which do not have the capacity to inhibit the variant forms of the enzyme.
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A Practical Oxone®-Mediated, High-Throughput, Solution-Phase Synthesis of Benzimidazoles from 1,2-Phenylenediamines and Aldehydes and its Application to Preparative Scale Synthesis
TL;DR: In this article, a mixture of a 1,2-phenylenedi-amine and an aldehyde in wet DMF at room temperature is used to synthesize benzimidazoles.
Journal ArticleDOI
Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles)
Terri A. Fairley,Richard R. Tidwell,Isaac O. Donkor,Noreen A. Naiman,Kwasi A. Ohemeng,Richard J. Lombardy,James A. Bentley,Michael Cory +7 more
TL;DR: Molecular modeling studies and the biophysical data suggest that the molecules bind to the minor groove of CT DNA and homopolymers and analysis of the shape of the molecules is consistent with this mode of nucleic acid binding.
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Silica functionalised sulphonic acid groups: synthesis, characterization and catalytic activity in acetalization and acetylation reactions
TL;DR: In this article, a simple synthesis procedure for the immobilization of propyl thiol groups on silica is investigated using various concentrations of 3-mercapto propyl trimethoxy silane (3-MPTS) in the range of 5-40%.