B. J. Druker

TL;DR: During the sixth year of study treatment, there were no reports of disease progression to accelerated phase (AP) or blast crisis (BC), and the toxicity profile was unchanged.

TL;DR: Cbl associates with all three forms of the human Crk protein, predominantly CrkL, following T cell receptor activation of Jurkat T cells, suggesting the possibility that Cbl may participate in a signaling pathway that regulates guanine nucleotide exchange on small G-proteins in T cells.

TL;DR: Age-adjusted population incidence and reported ARCH mutation rates are consistent with a model in which clinical CMML ensues when a sufficient number of stochastically acquired age-related mutations has accumulated, suggesting that CMML represents the leukemic conversion of the myelomonocytic-lineage-biased aged hematopoietic system.

TL;DR: The data suggest that the inducible Cbl-Crk association is a proximal component of a signaling pathway downstream of multiple cytokine receptors, and particularly important in factor-dependent hematopoietic cell lines.

TL;DR: The findings strongly support the role of Cbl, via its ubiquitin ligase activity, as a negative regulator of activated Vav, a hematopoietic-restricted Rac guanine nucleotide exchange factor.