B
B.K. Park
Researcher at University of Liverpool
Publications - 194
Citations - 9088
B.K. Park is an academic researcher from University of Liverpool. The author has contributed to research in topics: Metabolite & Microsome. The author has an hindex of 55, co-authored 192 publications receiving 8716 citations. Previous affiliations of B.K. Park include University of Bern & Western Infirmary.
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Journal ArticleDOI
The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: Chemical mechanisms and the effects of fluorine substitution
TL;DR: Findings indicate that the bioactivation of amodiaquine by PMN is associated with the formation of a quinoneimine intermediate, which, if produced in PMN or bone marrow in vivo, may be responsible for the drug's myelotoxicity.
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Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs
Dean J. Naisbitt,Dominic P. Williams,Paul M. O'Neill,James L. Maggs,David J. Willock,Munir Pirmohamed,B.K. Park +6 more
TL;DR: The data show that amodiaquine and related antimalarials containing a p-aminophenol moiety undergo bioactivation in vitro to chemically reactive and cytotoxic intermediates, and in particular, pyronaridine was metabolized to a compound which was toxic to neutrophils.
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Plasma disposition of vitamin K1 in relation to anticoagulant poisoning.
TL;DR: Experiments in brodifacoum-anticoagulated rabbits demonstrate that the duration of action of a pharmacological dose is short and that high plasma concentrations of the vitamin are required to drive clotting factor synthesis during maximum coumarin anticoagulation.
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Warfarin: metabolism and mode of action.
TL;DR: It is suggested that the coumarin ring system is largely responsible for the pharmacodynamic properties of warfarin, whereas the side-chain dictates the disposition and metabolism of the drug.
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The effect of rifampicin on norethisterone pharmacokinetics.
David Back,Alasdair Breckenridge,Francesca E. Crawford,M. MacIver,M L Orme,B.K. Park,P.H. Rowe,Eileen Smith +7 more
TL;DR: The changes in norethisterone pharmacokinetics during rifampicin therapy are compatible with the known enzyme inducing effect of rifampsicin.