B
B.K. Park
Researcher at University of Liverpool
Publications - 194
Citations - 9088
B.K. Park is an academic researcher from University of Liverpool. The author has contributed to research in topics: Metabolite & Microsome. The author has an hindex of 55, co-authored 192 publications receiving 8716 citations. Previous affiliations of B.K. Park include University of Bern & Western Infirmary.
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Journal ArticleDOI
Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome
Rowena Eakins,Joanne Walsh,Laura E. Randle,Rosalind E. Jenkins,Ina Schuppe-Koistinen,Cliff Rowe,P.J. Starkey Lewis,O Vasieva,Neus Prats,Nathalie Brillant,Mariona Aulí,Matthew B. Bayliss,Steven D. Webb,JA Rees,Neil R. Kitteringham,Christopher E. Goldring,B.K. Park +16 more
TL;DR: It is shown that adaptation to acetaminophen has a spatial component, involving a shift in regionalisation of CYP2E1, which may prevent toxicity thresholds being reached and reveal unexpected complexity and dynamic behaviour in the biological response to drug-induced liver injury.
Journal ArticleDOI
Assessment of enzyme induction and enzyme inhibition in humans: toxicological implications.
B.K. Park,N R Kitteringham +1 more
TL;DR: Combined pharmacokinetic/pharmacodynamic studies are required to assess the pharmacological relevance of either induction or inhibition of the enzymes involved in drug metabolism.
Journal ArticleDOI
Drug-specific antibodies in patients receiving captopril.
TL;DR: It appears that CP may be immunogenic in some patients receiving the drug, and the antibodies described are directed against CP in disulphide-linked form.
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A comparative study of the formation of chemically reactive drug metabolites by human liver microsomes.
TL;DR: The metabolism of amodiaquine (A), ethinyloestradiol (E), mianserin (M), phenytoin (Ph), sulphanilamide (S) and paracetamol (Pa) to both stable and chemically reactive metabolites was investigated using microsomes prepared from histologically normal human liver obtained from eight kidney donors.
Journal ArticleDOI
Enzyme-inducing drug combinations and their effects on liver microsomal enzyme activity in man.
TL;DR: A significantly greater increase in antipyrine clearance and 6-β-hydroxycortisol excretion was observed than when either drug was given alone, and this effect was slightly more induction than phenobarbitone given alone.