B
B.K. Park
Researcher at University of Liverpool
Publications - 194
Citations - 9088
B.K. Park is an academic researcher from University of Liverpool. The author has contributed to research in topics: Metabolite & Microsome. The author has an hindex of 55, co-authored 192 publications receiving 8716 citations. Previous affiliations of B.K. Park include University of Bern & Western Infirmary.
Papers
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Journal Article
The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man.
TL;DR: It is concluded that clozapine undergoes bioactivation in several tissues and considerable bio activation in vivo and the reactive metabolites generated by neutrophils and myeloid cells may play an important role in the metabolic causation of clozAPine-induced agranuiocytosis.
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N-Hydroxylation of dapsone by multiple enzymes of cytochrome P450 : implications for inhibition of haemotoxicity
Helen J. Gill,Tingle,B.K. Park +2 more
TL;DR: Data presented in this paper illustrate the involvement of more than one cytochrome P450 enzyme in dapsone hydroxylamine formation using human liver microsomes, and indicates that the contribution of individual CYP enzymes varies between livers.
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Metabolic activation in drug allergies.
TL;DR: The purpose of this review is to assess critically the evidence to support the hapten mechanism, and also to consider alternative mechanisms by which drugs cause idiosyncratic toxicity.
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Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury
A. D. B. Vliegenthart,Jonathan M Shaffer,Joanna I. Clarke,Laura E J Peeters,Andrea Caporali,D. N. Bateman,David M. Wood,David M. Wood,Paul I. Dargan,Paul I. Dargan,D G Craig,Joanna Moore,Alexandra I. Thompson,Neil C. Henderson,David J. Webb,Jack Sharkey,D.J. Antoine,B.K. Park,Matthew A. Bailey,Eric Lader,Kenneth J. Simpson,James W. Dear +21 more
TL;DR: Profiling of acetaminophen toxicity identified multiple miRNAs that report acute liver injury and potential biomarkers of drug-induced kidney injury that are associated with human kidney dysfunction.
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Comparison of the Metabolism and Toxicity of Dapsone in Rat, Mouse and Man
TL;DR: In this paper, the metabolism and toxicity of dapsone was compared in vitro and in vivo in rat, mouse and man, using high-pressure liquid chromatography-mass spectrometry and methemoglobin formation has been used as a toxic endpoint.