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B. Michael Ghadimi
Researcher at University of Göttingen
Publications - 136
Citations - 5229
B. Michael Ghadimi is an academic researcher from University of Göttingen. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 35, co-authored 103 publications receiving 4596 citations. Previous affiliations of B. Michael Ghadimi include University Medical Center & National Institutes of Health.
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Journal ArticleDOI
Effectiveness of Gene Expression Profiling for Response Prediction of Rectal Adenocarcinomas to Preoperative Chemoradiotherapy
B. Michael Ghadimi,Marian Grade,Michael J. Difilippantonio,Sudhir Varma,Richard Simon,Cristina Montagna,László Füzesi,Claus Langer,Heinz Becker,Torsten Liersch,Thomas Ried +10 more
TL;DR: The results suggest that pretherapeutic gene expression profiling may assist in response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy and the implementation of gene expression profiles for treatment stratification and clinical management of cancer patients requires validation in large, independent studies.
Journal Article
Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignant.
Tanja Fehm,Arthur I. Sagalowsky,Edward Clifford,Peter D. Beitsch,Hossein Saboorian,David M. Euhus,Songdong Meng,Larry E. Morrison,Thomas F. Tucker,Nancy Lane,B. Michael Ghadimi,Kerstin Heselmeyer-Haddad,Thomas Ried,Chandra Rao,Jonathan W. Uhr +14 more
TL;DR: It is concluded that the vast majority of CECs in breast, kidney, prostate, and colon cancer patients are aneusomic and derived from the primary tumor.
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Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations†
B. Michael Ghadimi,Dan L. Sackett,Michael J. Difilippantonio,Evelin Schröck,Thomas Neumann,Annukka Jauho,Gert Auer,Thomas Ried +7 more
TL;DR: The results indicate that the aneuploid tumor cell lines have an increased sensitivity to these reagents and a delay in aster formation and microtubule regrowth, but the notion that the integrity of the centrosome plays a central role in the development of aneuPLoidy is supported.
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Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer
Geng Zhang,Peijun He,Hanson Tan,Anuradha Budhu,Jochen Gaedcke,B. Michael Ghadimi,Thomas Ried,Harris G. Yfantis,Dong H. Lee,Anirban Maitra,Nader Hanna,H. Richard Alexander,S. Perwez Hussain +12 more
TL;DR: Impairment in a lipolytic pathway involving lipases, and a unique set of FFAs, may play an important role in the development and progression of pancreatic cancer and provide potential targets for therapeutic intervention.
Journal ArticleDOI
Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas.
B. Michael Ghadimi,Evelin Schröck,Robert L. Walker,Danny Wangsa,Annukka Jauho,Paul S. Meltzer,Thomas Ried +6 more
TL;DR: The comparison with comparative genomic hybridization data from primary pancreatic tumors indicates that a specific pattern of chromosomal copy number changes is maintained in cell culture, and chromosomal rearrangements identified in these cell lines were unbalanced.