M
Marian Grade
Researcher at University of Göttingen
Publications - 90
Citations - 3372
Marian Grade is an academic researcher from University of Göttingen. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 29, co-authored 84 publications receiving 2931 citations. Previous affiliations of Marian Grade include National Institutes of Health & University Medical Center.
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Journal ArticleDOI
Effectiveness of Gene Expression Profiling for Response Prediction of Rectal Adenocarcinomas to Preoperative Chemoradiotherapy
B. Michael Ghadimi,Marian Grade,Michael J. Difilippantonio,Sudhir Varma,Richard Simon,Cristina Montagna,László Füzesi,Claus Langer,Heinz Becker,Torsten Liersch,Thomas Ried +10 more
TL;DR: The results suggest that pretherapeutic gene expression profiling may assist in response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy and the implementation of gene expression profiles for treatment stratification and clinical management of cancer patients requires validation in large, independent studies.
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Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas.
Jochen Gaedcke,Marian Grade,Klaus Jung,Jordi Camps,Peter Jo,Georg Emons,Anastasia Gehoff,Ulrich Sax,Markus D. Schirmer,Heinz Becker,Tim Beissbarth,Thomas Ried,B. Michael Ghadimi +12 more
TL;DR: Findings suggest a potential approach to overcome resistance to treatment with antibodies against the epithelial growth factor receptor in patients with KRAS‐mutant rectal carcinomas.
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Impact of RNA degradation on gene expression profiling
Lennart Opitz,Gabriela Salinas-Riester,Marian Grade,Klaus Jung,Peter Jo,Georg Emons,B. Michael Ghadimi,Tim Beißbarth,Jochen Gaedcke +8 more
TL;DR: Degraded RNA from tumor samples (RIN > 5) can still be used to perform gene expression analysis, but there are genes, very short ones and those with the probe binding side close to the 5' end that should be excluded from gene expressionAnalysis when working with degraded RNA.
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The Rectal Cancer microRNAome – microRNA Expression in Rectal Cancer and Matched Normal Mucosa
Jochen Gaedcke,Marian Grade,Jordi Camps,Rolf Søkilde,Bogumil Kaczkowski,Aaron J. Schetter,Michael J. Difilippantonio,Curtis C. Harris,B. Michael Ghadimi,Søren Møller,Tim Beissbarth,Thomas Ried,Thomas Litman +12 more
TL;DR: This comprehensive analysis of the rectal cancer miRNAome uncovered novel miRNAs and pathways associated withrectal cancer, and the identification and validation of miR-135b may help to identify novel molecular targets and pathways for therapeutic exploitation.
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The mesopancreas is the primary site for R1 resection in pancreatic head cancer: relevance for clinical trials.
Jochen Gaedcke,Bastian Gunawan,Marian Grade,R. E. Szöke,Torsten Liersch,H. D. Becker,B. M. Ghadimi +6 more
TL;DR: Using the intensified histopathological workup for pancreatic head cancer specimens resulted in an increased rate of R1 resections and the mesopancreas represents the primary site for positive resection margins, of relevance for patients’ stratification in clinical trials.