B
Badri Modi
Researcher at City of Hope National Medical Center
Publications - 31
Citations - 1468
Badri Modi is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 24 publications receiving 1015 citations. Previous affiliations of Badri Modi include University of Pennsylvania & Yale University.
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Journal ArticleDOI
PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma
Michael R. Migden,Danny Rischin,Chrysalyne D. Schmults,Alexander Guminski,Axel Hauschild,Karl D. Lewis,Christine H. Chung,Leonel Hernandez-Aya,Annette M. Lim,Anne Lynn S. Chang,Guilherme Rabinowits,Alesha A. Thai,Lara Dunn,Brett G.M. Hughes,Nikhil I. Khushalani,Badri Modi,Dirk Schadendorf,Bo Gao,Frank Seebach,Siyu Li,Jingjin Li,Melissa Mathias,Jocelyn Booth,Kosalai Kal Mohan,Elizabeth Stankevich,Hani M. Babiker,Irene Brana,Marta Gil-Martin,Jade Homsi,Melissa Lynne Johnson,Victor Moreno,Jiaxin Niu,Taofeek K. Owonikoko,Kyriakos P. Papadopoulos,George D. Yancopoulos,Israel Lowy,Matthew G. Fury +36 more
TL;DR: Among patients with advanced cutaneous squamous‐cell carcinoma, cemiplimab induced a response in approximately half the patients and was associated with adverse events that usually occur with immune checkpoint inhibitors.
Journal ArticleDOI
Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma
Badri Modi,Jason H. Neustadter,Elisa Binda,Elisa Binda,Julia M. Lewis,Renata B. Filler,Scott J. Roberts,Bernice Y. Kwong,Swapna Reddy,John D. Overton,Anjela Galan,Robert E. Tigelaar,Lining Cai,Peter P. Fu,Mark J. Shlomchik,Daniel H. Kaplan,Adrian Hayday,Adrian Hayday,Michael Girardi +18 more
TL;DR: Tissue-associated DC can enhance chemical carcinogenesis via PAH metabolism, highlighting the complex relation between immune cells and carcinogenesis.
Journal ArticleDOI
Cortical Deactivation Induced by Subcortical Network Dysfunction in Limbic Seizures
TL;DR: It is found through functional magnetic resonance imaging (fMRI) that electrically stimulated hippocampal seizures in rats cause increased activity in subcortical structures including the septal area and mediodorsal thalamus, along with reduced activity in frontal, cingulate, and retrosplenial cortex.
Journal ArticleDOI
Phase 2 study of cemiplimab in patients with metastatic cutaneous squamous cell carcinoma: primary analysis of fixed-dosing, long-term outcome of weight-based dosing
Danny Rischin,Michael R. Migden,Annette M. Lim,Chrysalyne D. Schmults,Nikhil I. Khushalani,Brett G.M. Hughes,Dirk Schadendorf,Lara Dunn,Leonel Hernandez-Aya,Anne Lynn S. Chang,Badri Modi,Axel Hauschild,Claas Ulrich,Thomas Eigentler,Brian Stein,Anna C. Pavlick,Jessica L. Geiger,Ralf Gutzmer,Murad Alam,Emmanuel Okoye,Melissa Mathias,Vladimir Jankovic,Elizabeth Stankevich,Jocelyn Booth,Siyu Li,Israel Lowy,Matthew G. Fury,Alexander Guminski +27 more
TL;DR: In patients with mCSCC, cemiplimab 350 mg intravenously Q3W produced substantial antitumor activity with durable response and an acceptable safety profile, and follow-up data of cemplimab 3mg/kg intravenous Q2W demonstrate ongoing durability of responses.
Journal ArticleDOI
Ruxolitinib as Salvage Therapy for Chronic Graft-versus-Host Disease.
Badri Modi,Michael Hernandez-Henderson,Dongyun Yang,Jeremy Klein,Sanjeet Dadwal,Erin Kopp,Karen Huelsman,Sally Mokhtari,Haris Ali,Monzr M. Al Malki,Ricardo Spielberger,Amandeep Salhotra,Jasmine Zain,Jonathan Cotliar,Pablo Parker,Stephen J. Forman,Ryotaro Nakamura +16 more
TL;DR: The data support the use of ruxolitinib for cGVHD refractory to steroids and currently available salvage therapies, discontinued due to lack of response and high cost.