D
Daniel H. Kaplan
Researcher at University of Pittsburgh
Publications - 117
Citations - 12510
Daniel H. Kaplan is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 45, co-authored 112 publications receiving 10371 citations. Previous affiliations of Daniel H. Kaplan include Yale University & University of Minnesota.
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Journal ArticleDOI
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
Marco A Meraz,Marco A Meraz,J. Michael White,Kathleen C. F. Sheehan,Erika A. Bach,Scott J. Rodig,Anand S. Dighe,Daniel H. Kaplan,Joan K. Riley,Andrew C. Greenlund,Dayle Campbell,Karen Carver-Moore,Raymond N. DuBois,Ross G. Clark,Michel Aguet,Michel Aguet,Robert D. Schreiber +16 more
TL;DR: These observations document that STAT1 plays an obligate and dedicated role in mediating IFN-dependent biologic responses and reveal an unexpected level of physiologic specificity for STAT1 action.
Journal ArticleDOI
Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice
Daniel H. Kaplan,Vijay Shankaran,Anand S. Dighe,Elisabeth Stockert,Michel Aguet,Lloyd J. Old,Robert D. Schreiber +6 more
TL;DR: It is demonstrated that endogenously produced interferon gamma (IFN-gamma) forms the basis of a tumor surveillance system that controls development of both chemically induced and spontaneously arising tumors in mice and is evidenced by the finding that certain types of human tumors become selectively unresponsive to IFN-Gamma.
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Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity.
TL;DR: It is found that contact hypersensitivity (CHS) was amplified rather than abrogated in the absence of LCs, and LCs not only were dispensable for CHS, but they served to regulate the response, a previously unappreciated function.
Journal ArticleDOI
Identification of a novel population of Langerin+ dendritic cells
Laura S. Bursch,Liangchun Wang,Botond Z. Igyártó,Adrien Kissenpfennig,Bernard Malissen,Daniel H. Kaplan,Kristin A. Hogquist +6 more
TL;DR: This work has discovered a novel population of LCs that resides in the dermis and does not represent migrating epidermal LCs, as previously thought, and suggests that dermalLCs can mediate contact hypersensitivity responses.
Journal ArticleDOI
Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics.
Alan Menter,Bruce Strober,Daniel H. Kaplan,Dario Kivelevitch,Elizabeth Farley Prater,Benjamin K. Stoff,April W. Armstrong,Cody Connor,Kelly M. Cordoro,Dawn Marie R. Davis,Boni E. Elewski,Joel M. Gelfand,Kenneth B. Gordon,Alice B. Gottlieb,Arthur Kavanaugh,Matthew Kiselica,Neil J. Korman,Daniela Kroshinsky,Mark Lebwohl,Craig L. Leonardi,Jason Lichten,Henry W. Lim,Nehal N. Mehta,Amy S. Paller,Sylvia L. Parra,Arun L. Pathy,Reena N. Rupani,Michael Siegel,Emily B. Wong,Jashin J. Wu,Vidhya Hariharan,Craig A. Elmets +31 more
TL;DR: The treatment of psoriasis with biologic agents will be reviewed, emphasizing treatment recommendations and the role of the dermatologist in monitoring and educating patients regarding benefits as well as associated risks.