B
Bahar Yilmazel
Researcher at Foundation Medicine
Publications - 11
Citations - 635
Bahar Yilmazel is an academic researcher from Foundation Medicine. The author has contributed to research in topics: Primary Induction Failure & Gene mutation. The author has an hindex of 6, co-authored 10 publications receiving 519 citations. Previous affiliations of Bahar Yilmazel include Northeastern University & Harvard University.
Papers
More filters
Journal ArticleDOI
Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets
Arunachalam Vinayagam,Travis E. Gibson,Ho-Joon Lee,Bahar Yilmazel,Charles Roesel,Charles Roesel,Yanhui Hu,Young Guen Kwon,Amitabh Sharma,Yang-Yu Liu,Yang-Yu Liu,Yang-Yu Liu,Norbert Perrimon,Albert-László Barabási +13 more
TL;DR: It is found that 21% of the proteins in the PPI network are indispensable, Interestingly, these indispensable proteins are the primary targets of disease-causing mutations, human viruses, and drugs, suggesting that altering a network’s control property is critical for the transition between healthy and disease states.
Journal ArticleDOI
Integrating protein-protein interaction networks with phenotypes reveals signs of interactions
Arunachalam Vinayagam,Jonathan Zirin,Charles Roesel,Yanhui Hu,Bahar Yilmazel,Anastasia Samsonova,Ralph A. Neumüller,Stephanie E. Mohr,Norbert Perrimon +8 more
TL;DR: A computational framework to integrate protein-protein interaction (PPI) networks and genetic screens to predict the 'signs' of interactions and identified an unexpected role for the metabolic enzymes enolase and aldo-keto reductase as positive and negative regulators of proteolysis, respectively.
Journal ArticleDOI
Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi.
Benjamin E. Housden,Alexander J. Valvezan,Colleen F. Kelley,Richelle Sopko,Yanhui Hu,Charles Roesel,Shuailiang Lin,Michael Buckner,Rong Tao,Bahar Yilmazel,Stephanie E. Mohr,Brendan D. Manning,Norbert Perrimon,Norbert Perrimon +13 more
TL;DR: A CRISPR-based method to generate homogeneous mutant Drosophila cell lines is developed and individual knockdown of three candidate genes had similar growth-inhibiting effects in mammalian TSC2-deficient cell lines, illustrating the power of this cross-species screening strategy to identify potential drug targets.
Journal ArticleDOI
RET rearrangements are actionable alterations in breast cancer
Bhavna S. Paratala,Jon Chung,Casey Williams,Bahar Yilmazel,Whitney Petrosky,Kirstin Williams,Alexa B. Schrock,Ellen Lee,Sonia C. Dolfi,Kien Pham,Stephanie Lin,Ming Yao,Atul Kulkarni,Frances DiClemente,Chen Liu,Lorna Rodriguez-Rodriguez,Shridar Ganesan,Jeffrey S. Ross,Siraj M. Ali,Brian Leyland-Jones,Kim M. Hirshfield +20 more
TL;DR: The AUs identify RET gene alterations that are involved in the tumorigenic process and show the benefit of RET therapy in a recurrent BC patient carrying the NCOA4-RET fusion.
Journal ArticleDOI
Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis.
Bahar Yilmazel,Yanhui Hu,Frederic Sigoillot,Jennifer A. Smith,Caroline E. Shamu,Norbert Perrimon,Norbert Perrimon,Stephanie E. Mohr +7 more
TL;DR: A user-friendly web application that provides researchers a relatively quick and easy way to perform genome-wide Enrichment of Seed Sequence matches (GESS) analysis on data from human or mouse cell-based screens using short interfering RNAs or short hairpin RNAs, as well as for Drosophila screens using shRNAs.