R
Ralph A. Neumüller
Researcher at Boehringer Ingelheim
Publications - 29
Citations - 2883
Ralph A. Neumüller is an academic researcher from Boehringer Ingelheim. The author has contributed to research in topics: Stem cell & Cell division. The author has an hindex of 16, co-authored 24 publications receiving 2472 citations. Previous affiliations of Ralph A. Neumüller include Austrian Academy of Sciences & Harvard University.
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Journal ArticleDOI
The Transgenic RNAi Project at Harvard Medical School: Resources and Validation
Lizabeth A. Perkins,Laura Holderbaum,Rong Tao,Yanhui Hu,Richelle Sopko,Kim McCall,Donghui Yang-Zhou,Ian Flockhart,Richard Binari,Richard Binari,Hye Seok Shim,Audrey Miller,Amy Housden,Marianna Foos,Sakara Randkelv,Colleen F. Kelley,Pema Namgyal,Christians Villalta,Christians Villalta,Lu Ping Liu,Lu Ping Liu,Xia Jiang,Qiao Huan-Huan,Xia Wang,Asao Fujiyama,Atsushi Toyoda,Kathleen Ayers,Allison Blum,Allison Blum,Benjamin Czech,Ralph A. Neumüller,Dong Yan,Amanda Cavallaro,Karen L. Hibbard,Donald Hall,Lynn Cooley,Gregory J. Hannon,Ruth Lehmann,Ruth Lehmann,Annette L. Parks,Stephanie E. Mohr,Ryu Ueda,Shu Kondo,Shu Kondo,Jian-Quan Ni,Jian-Quan Ni,Norbert Perrimon,Norbert Perrimon +47 more
TL;DR: The various tools developed and the status of the TRiP collection, which is currently composed of 11,491 lines and covering 71% of Drosophila genes, are described.
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Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer
TL;DR: The relevance of asymmetric cell divisions in various stem cell systems is summarized and why defects in asymmetrical cell division can lead to the formation of tumors are discussed.
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RNAi screening comes of age: improved techniques and complementary approaches
TL;DR: The recent availability of genome-editing strategies, such as the CRISPR (clustered regularly interspaced short palindromic repeats)–Cas9 system, when combined with RNAi could lead to further improvements in screen data quality and follow-up experiments, thus promoting the understanding of gene function and gene regulatory networks.
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The Drosophila NuMA Homolog Mud Regulates Spindle Orientation in Asymmetric Cell Division
Sarah K. Bowman,Ralph A. Neumüller,Maria Novatchkova,Maria Novatchkova,Quansheng Du,Juergen A. Knoblich +5 more
TL;DR: The data suggest a model in which asymmetrically localized Pins-G alphai complexes regulate spindle orientation by directly binding to Mud, the Drosophila homolog of NuMA, which can bind to microtubules and enhance microtubule polymerization.
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Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi
Ralph A. Neumüller,Constance Richter,Anja Fischer,Maria Novatchkova,Maria Novatchkova,Klaus G. Neumüller,Juergen A. Knoblich +6 more
TL;DR: The data identify key roles for the chromatin remodeling Brm complex, the spliceosome, and the TRiC/CCT-complex and show that the alternatively spliced transcription factor Lola and the transcriptional elongation factors Ssrp and Barc control self-renewal in neuroblast lineages.