B
Balaraman Kalyanaraman
Researcher at Medical College of Wisconsin
Publications - 488
Citations - 42413
Balaraman Kalyanaraman is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Radical & Superoxide. The author has an hindex of 100, co-authored 475 publications receiving 38562 citations. Previous affiliations of Balaraman Kalyanaraman include University of Alabama at Birmingham & University of Alabama.
Papers
More filters
Journal ArticleDOI
Nitric oxide donor compounds inhibit the toxicity of oxidized low-density lipoprotein to endothelial cells
TL;DR: It is proposed that nitric oxide, released from these compounds, is inhibiting the toxicity of LOOH to selenium‐deficient endothelial cells and that the mechanism for this inhibition of toxicity is the scavenging of the propagatory peroxyl and alkoxyl free radicals, by nitricoxide, that are generated during peroxidation of cell membranes.
Journal ArticleDOI
Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy
Timothy M. Brenza,Shivani Ghaisas,Julia E. Vela Ramirez,Dilshan S. Harischandra,Vellareddy Anantharam,Balaraman Kalyanaraman,Anumantha G. Kanthasamy,Balaji Narasimhan +7 more
TL;DR: The delivery of biodegradable polyanhydride nanoparticles containing the mitochondria-targeted antioxidant apocynin to neuronal cells and the ability of the nano-formulation to protect cells against oxidative stress are investigated.
Journal ArticleDOI
An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering
Elizabeth Ntantie,Patrick Gonyo,Ellen L. Lorimer,Andrew D. Hauser,Nathan J. Schuld,Donna McAllister,Balaraman Kalyanaraman,Michael B. Dwinell,John A. Auchampach,Carol L. Williams +9 more
TL;DR: The findings support a model in which high concentrations of extracellular adenosine, such as those that arise in the tumor microenvironment, can chronically activate A2B receptors to suppress Rap1B prenylation and signaling at the cell membrane, resulting in reduced cell-cell contact and promoting cell scattering.
Journal ArticleDOI
Peroxidatic oxidation of catecholamines. A kinetic electron spin resonance investigation using the spin stabilization approach.
TL;DR: Using spin stabilization, ESR measurements have been made of o-semiquinone production from the horseradish peroxidase-H2O2 oxidation of catecholamine substrates and the effects of phenol and ascorbate were studied and shown to be consistent with scavenging of phenoxyl radicals by catechlamine and semiquinones radicals by ascorBate.
Journal ArticleDOI
Detection of mitochondria-generated reactive oxygen species in cells using multiple probes and methods: Potentials, pitfalls, and the future
Gang Cheng,Monika Zielonka,Brian P. Dranka,Suresh Kumar,Charles R. Myers,Brian Bennett,Alexander M. Garces,Luiz Gabriel Dias Duarte Machado,David Thiebaut,Olivier Ouari,Micael Hardy,Jacek Zielonka,Balaraman Kalyanaraman +12 more
TL;DR: This work proposes the use of multiple probes and complementary techniques and the measurement of intracellular probe uptake and specific marker products to identify specific ROS generated in cells and the low-temperature EPR technique developed to investigate cellular/mitochondrial oxidants can easily be extended to animal and human tissues.