J
Jingyu Chen
Researcher at University of Southern California
Publications - 11
Citations - 443
Jingyu Chen is an academic researcher from University of Southern California. The author has contributed to research in topics: Protein kinase B & PTEN. The author has an hindex of 4, co-authored 10 publications receiving 216 citations.
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Journal ArticleDOI
PTEN: Tumor Suppressor and Metabolic Regulator.
TL;DR: The role of PTEN in glycolysis, gluconeogenesis, glycogen synthesis, lipid metabolism as well as mitochondrial metabolism, and the PTEN-regulated signals in metabolic regulation were focused on.
Journal ArticleDOI
Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis.
Anketse Debebe,Vivian Medina,C. Y. Chen,I. M. Mahajan,C. Jia,C. Jia,D. Fu,Lina He,Ni Zeng,B. W. Stiles,Chien-Yu Chen,M. Wang,K. R. Aggarwal,Zhechu Peng,Jen-Ming Huang,Jingyu Chen,Meng Li,T. Dong,S. Atkins,Zea Borok,W. Yuan,K. Machida,Changqing Ju,Michael Kahn,Deborah L. Johnson,Bangyan L. Stiles +25 more
TL;DR: Wnt/β-catenin is established as a novel signal produced by infiltrating macrophages induced by steatosis that promotes growth of tumor progenitor cells, underlying the increased risk of liver tumor development in obese individuals.
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AKT1 Regulates Endoplasmic Reticulum Stress and Mediates the Adaptive Response of Pancreatic β Cells.
Zhechu Peng,Richa Aggarwal,Ni Zeng,Lina He,Eileen X. Stiles,Anketse Debebe,Jingyu Chen,Chien-Yu Chen,Bangyan L. Stiles +8 more
TL;DR: It is shown that AKT1 protein loss led to the induction of eukaryotic initiation factor 2 α subunit (eIF2α) signaling and ER stress markers under normal-chow-fed conditions, indicating chronic low-level ER stress.
Journal ArticleDOI
Dual-Specific Protein and Lipid Phosphatase PTEN and Its Biological Functions.
TL;DR: Crystal structure analysis of PTEN has revealed a C2 domain that binds to phospholipids in membranes and a phosphatase domain that displays dual-specific activity toward both tyrosine (Y), serine (S)/threonine (T), as well as lipid substrates in vitro.
Journal ArticleDOI
Transformation of SOX9+ cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma.
TL;DR: In this article, a liver cancer mouse model was developed where tumor suppressor Pten (phosphatase and tensin homolog deleted on chromosome ten) is deleted in SOX9+ cells following tamoxifen injection.