Matthias Groszer

TL;DR: It is demonstrated that the PTEN tumor suppressor plays an important role in regulating neural stem/progenitor cells in vivo and in vitro, and results suggest that PTEN negatively regulates neural stem cell proliferation.

TL;DR: The FOXP2-CNTNAP2 pathway provides a mechanistic link between clinically distinct syndromes involving disrupted language, and is found to be associated with language delays in children with autism.

TL;DR: It is shown in the adult mouse retina that acute hypoxia dose-dependently stimulates expression of Epo, fibroblast growth factor 2 and vascular endothelial growth factor via Hypoxia-inducible factor-1α (HIF-1 α) stabilization.

TL;DR: In the striatum, a part of the basal ganglia affected in humans with a speech deficit due to a nonfunctional FOXP2 allele, it is found that medium spiny neurons have increased dendrite lengths and increased synaptic plasticity, suggesting that alterations in cortico-basal ganglia circuits might have been important for the evolution of speech and language in humans.

TL;DR: The results suggest that both EPO and EPOR are essential for early embryonic neural development and that the classical EPOR is important for adult neurogenesis and for migration of regenerating neurons during post-injury recovery.