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Shunyou Wang
Researcher at University of California, Los Angeles
Publications - 15
Citations - 3522
Shunyou Wang is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Prostate cancer & PTEN. The author has an hindex of 14, co-authored 14 publications receiving 3295 citations. Previous affiliations of Shunyou Wang include Vancouver General Hospital & University of Washington.
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Journal ArticleDOI
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
Shunyou Wang,Jing Gao,Qun-Ying Lei,Nora Rozengurt,Colin Pritchard,Jing Jiao,George Thomas,Gang Li,Pradip Roy-Burman,Peter S. Nelson,Xin Liu,Hong Wu +11 more
TL;DR: Global assessment of molecular changes caused by homozygous Pten deletion identified key genes known to be relevant to human prostate cancer, including those "signature" genes associated with human cancer metastasis.
Journal Article
Prostate-localized and Androgen-regulated Expression of the Membrane-bound Serine Protease TMPRSS2
Biaoyang Lin,Camari Ferguson,James T. White,Shunyou Wang,Robert L. Vessella,Lawrence D. True,Leroy Hood,Peter S. Nelson +7 more
TL;DR: Results suggest that TMPRSS2 may play a role in prostate carcinogenesis and should be investigated as a diagnostic or therapeutic target for the management of prostate cancers.
Journal ArticleDOI
Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth
David J. Mulholland,Linh M. Tran,Yunfeng Li,Houjian Cai,Ashkan Morim,Shunyou Wang,Seema B. Plaisier,Isla P. Garraway,Jiaoti Huang,Thomas G. Graeber,Hong Wu +10 more
TL;DR: It is shown that castration-resistant growth is an intrinsic property of Pten null prostate cancer (CaP) cells, independent of cancer development stage, with potentially important implications for CaP etiology and therapy.
Journal ArticleDOI
Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation
TL;DR: Using defined cell lineage markers, it is demonstrated that PTEN negatively regulates p63-positive prostatic basal cell proliferation without blocking differentiation, providing strong evidence that basalcell proliferation can be an initiating event for precancerous lesions.
Journal ArticleDOI
PTENless means more.
TL;DR: The function of PTEN in murine development and its role in regulating stem cell self-renewal and proliferation are focused on and the organomegaly phenotypes associated with Pten tissue-specific deletion are summarized.