Handbook of solubility data for pharmaceuticals , Handbook of solubility data for pharmaceuticals , کتابخانه دیجیتال جندی شاپور اهواز

http://chemistry-chemists.com/chemister/Spravochniki/handbook-of-solubility-data-for-pharmaceuticals-2010.pdf

Handbook of Solubility Data for Pharmaceuticals

As a novel class of porous crystalline materials, hydrogen-bonded organic frameworks (HOFs), self-assembled from organic or metal-organic building blocks through intermolecular hydrogen-bonding interactions, have attracted more and more attention. Over the past decade, a number of porous HOFs have been constructed through judicious selection of H-bonding motifs, which are further enforced by other weak intermolecular interactions such as π-π stacking and van der Waals forces and framework interpenetration. Since the H-bonds are weaker than coordinate and covalent bonds used for the construction of metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), HOFs have some unique features such as mild synthesis condition, solution processability, easy healing, and regeneration. These features enable HOFs to be a tunable platform for the construction of functional materials. Here, we review the H-bonding motifs used for constructing porous HOFs and highlight some of their applications, including gas separation and storage, chiral separation and structure determination, fluorescent sensing, heterogeneous catalysis, biological applications, proton conduction, photoluminescent materials, and membrane-based applications.

Hydrogen-Bonded Organic Frameworks as a Tunable Platform for Functional Materials.

The 31 P NMR spectra of triethylphosphine oxide (Et 3 PO) undergoes a shift upon interaction in solution with adjacent molecules. The oxygen of Et 3 PO is a strong electron donor and readily forms acid-base complexes with electron acceptors, with a consequent downfield shift in the 31 P NMR spectrum (Δδ ab ). We find that the 31 P NMR spectrum also is shifted downfield appreciably by van der Waals (largery dispersion force) interactions with solvents (Δδ d )

Spectral shifts in acid-base chemistry. II: Van der Waals contributions to acceptor numbers

An analytical model for spontaneous imbibition in fractal porous media including gravity

Poly(lactic acid) (PLA) is the most used biopolymer for food packaging applications. Several strategies have been made to improve PLA properties for extending its applications in the packaging field. Melt blending approaches are gaining considerable interest since they are easy, cost-effective and readily available processing technologies at the industrial level. With a similar melting temperature and high crystallinity, poly(hydroxybutyrate) (PHB) represents a good candidate to blend with PLA. The ability of PHB to act as a nucleating agent for PLA improves its mechanical resistance and barrier performance. With the dual objective to improve PLAPHB processing performance and to obtain stretchable materials, plasticizers are frequently added. Current trends to enhance PLA-PHB miscibility are focused on the development of composite and nanocomposites. PLA-PHB blends are also interesting for the controlled release of active compounds in the development of active packaging systems. This review explains the most relevant processing aspects of PLA-PHB based blends such as the influence of polymers molecular weight, the PLA-PHB composition as well as the thermal stability. It also summarizes the recent developments in PLA-PHB formulations with an emphasis on their performance with interest in the sustainable food packaging field. PLA-PHB blends shows highly promising perspectives for the replacement of traditional petrochemical based polymers currently used for food packaging.

On the Use of PLA-PHB Blends for Sustainable Food Packaging Applications

Determination and correlation of solubility of 11α,17α-dihydroxy-4-pregnene-3,20-dione in different solvents

4,4′-Oxydianiline (ODA) is a versatile fine chemical intermediate with huge market demand. The purification of ODA is accomplished by crystallization with some high-boiling-point liquids as solvent...

Measurement and Correlation of the Solubility of 4,4′-Oxydianiline in Four Binary Solvent Mixtures from T = 293.15 to 333.15 K

In this paper a porous media seepage model was applied to analyze the permeability and study the seepage process of crystal pillar formed in the preparation of electronic grade phosphoric acid (EGPA). By inspecting the seeping process, the structure parameter of crystal pillar could be obtained. Two basic ideal models (perfectly separated model and perfectly connected model) were presented and a characterized factor φ was introduced to modify the model. A good simulation result was obtained which met the experiment result well. The relationship between φ and permeability were also discussed. The characterized factor φ showed potential application on optimizing process.

Permeability analysis and seepage process study on crystal layer in melt crystallization with fractal and porous media theory

The invention relates to a preparation method of a hollow polymer drug-loaded nano-rod. The preparation method comprises the following steps of carrying out induction adsorption of a fat-soluble drug by mesoporous silica, carrying out surface modification, loading a polymer on a silica template surface by an appropriate coating method so that the fat-soluble drug is coated in channels of the mesoporous silica, and carrying out hydrofluoric acid etching, wherein the fat-soluble drug is aggregated in a hydrofluoric acid solution and still stays in the hollow polymer rods and thus the hollow polymer drug-loaded nano-rods are obtained. The hollow polymer drug-loaded nano-rod has a regular shape, good dispersibility, an adjustable particle size and a drug entrapment rate of 10 to 20% and can be used as a novel drug carrier and for a fat-soluble administration system. The preparation method has the advantages of safety, low toxicity, simple and feasible operation, good repeatability, low cost and large-scale production feasibility.

Preparation method of hollow polymer drug-loaded nano-rod

The invention relates to a method for preparing penicillin-G-1-(S)-oxide. In the method, penicillin G is used as a raw material, and the oxidization of the penicillin G and the crystallization of penicillin-G-1-(S)-oxide which is the oxidization product of the penicillin G are performed at the same time. A penicillin-G-1-(S)-oxide crystal product is obtained by directly adding an oxidant into penicillin G organic phase solution, reacting and crystallizing, the oxidization reaction and the crystallization are performed at the same time, and the crystal product directly precipitates in organic solution. Compared with the conventional direct oxidization process, the method has the advantages that: the operation flow is simplified considerably; the operation is simple and convenient; the labor intensity is lowered; and the production period is shortened obviously. The process of extracting the penicillin G from the organic phase back to a water phase and the process of regulating pH value with diluted acid and crystallizing are saved, so the consumption of waster resources is reduced greatly, the discharge of waste acid liquor is reduced, and the problem of environmental pollution is alleviated obviously. The high-performance liquid chromatography (HPLC) content of the product reaches over 99.0 percent, and the weight yield of products with a main particle size over 30 mu m is over 90 percent.

Baohong Hou

Papers

Determination and correlation of solubility of 11α,17α-dihydroxy-4-pregnene-3,20-dione in different solvents

Measurement and Correlation of the Solubility of 4,4′-Oxydianiline in Four Binary Solvent Mixtures from T = 293.15 to 333.15 K

Permeability analysis and seepage process study on crystal layer in melt crystallization with fractal and porous media theory

Preparation method of hollow polymer drug-loaded nano-rod

Method for preparing penicillin-G-1-(S)-oxide