Handbook of solubility data for pharmaceuticals , Handbook of solubility data for pharmaceuticals , کتابخانه دیجیتال جندی شاپور اهواز

http://chemistry-chemists.com/chemister/Spravochniki/handbook-of-solubility-data-for-pharmaceuticals-2010.pdf

Handbook of Solubility Data for Pharmaceuticals

As a novel class of porous crystalline materials, hydrogen-bonded organic frameworks (HOFs), self-assembled from organic or metal-organic building blocks through intermolecular hydrogen-bonding interactions, have attracted more and more attention. Over the past decade, a number of porous HOFs have been constructed through judicious selection of H-bonding motifs, which are further enforced by other weak intermolecular interactions such as π-π stacking and van der Waals forces and framework interpenetration. Since the H-bonds are weaker than coordinate and covalent bonds used for the construction of metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), HOFs have some unique features such as mild synthesis condition, solution processability, easy healing, and regeneration. These features enable HOFs to be a tunable platform for the construction of functional materials. Here, we review the H-bonding motifs used for constructing porous HOFs and highlight some of their applications, including gas separation and storage, chiral separation and structure determination, fluorescent sensing, heterogeneous catalysis, biological applications, proton conduction, photoluminescent materials, and membrane-based applications.

Hydrogen-Bonded Organic Frameworks as a Tunable Platform for Functional Materials.

The 31 P NMR spectra of triethylphosphine oxide (Et 3 PO) undergoes a shift upon interaction in solution with adjacent molecules. The oxygen of Et 3 PO is a strong electron donor and readily forms acid-base complexes with electron acceptors, with a consequent downfield shift in the 31 P NMR spectrum (Δδ ab ). We find that the 31 P NMR spectrum also is shifted downfield appreciably by van der Waals (largery dispersion force) interactions with solvents (Δδ d )

Spectral shifts in acid-base chemistry. II: Van der Waals contributions to acceptor numbers

An analytical model for spontaneous imbibition in fractal porous media including gravity

Poly(lactic acid) (PLA) is the most used biopolymer for food packaging applications. Several strategies have been made to improve PLA properties for extending its applications in the packaging field. Melt blending approaches are gaining considerable interest since they are easy, cost-effective and readily available processing technologies at the industrial level. With a similar melting temperature and high crystallinity, poly(hydroxybutyrate) (PHB) represents a good candidate to blend with PLA. The ability of PHB to act as a nucleating agent for PLA improves its mechanical resistance and barrier performance. With the dual objective to improve PLAPHB processing performance and to obtain stretchable materials, plasticizers are frequently added. Current trends to enhance PLA-PHB miscibility are focused on the development of composite and nanocomposites. PLA-PHB blends are also interesting for the controlled release of active compounds in the development of active packaging systems. This review explains the most relevant processing aspects of PLA-PHB based blends such as the influence of polymers molecular weight, the PLA-PHB composition as well as the thermal stability. It also summarizes the recent developments in PLA-PHB formulations with an emphasis on their performance with interest in the sustainable food packaging field. PLA-PHB blends shows highly promising perspectives for the replacement of traditional petrochemical based polymers currently used for food packaging.

On the Use of PLA-PHB Blends for Sustainable Food Packaging Applications

In the title complex, {[Ag(C9H8N4S2)(C2H3N)]BF4}n, the AgI atom shows trigonal–planar coordination, as it is coordinated by the N atoms from two bis­(pyrimidin-2-ylsulfan­yl)methane mol­ecules and the N-atom donor of an acetonitrile mol­ecule. The manner in which the donor mol­ecules connect to the Ag atoms leads to a linear chain structure. Adjacent chains are connected into a layer via weak Ag⋯S inter­actions.

catena-Poly[[[(acetonitrile-κN)silver(I)]-μ-bis­(pyrimidin-2-ylsulfan­yl)methane-κ2N1:N1′] tetra­fluoro­borate]

Reply to “commentary on ‘effect of β-alanine and the solvent composition on the solubility of solvate of calcium d-pantothenate containing four molecules of methanol and one molecule of water (d-PC·4MeOH·1H2O)’”

Disclosed are an omeprazole sodium semihydrate and a preparation method therefor. One mole of omeprazole sodium semihydrate contains 0.5 mole of water, and the X-ray diffraction spectrum thereof has characteristic peaks at diffraction angles 2θ of 6.26±0.1, 11.10±0.1, 12.20±0.1, 15.58±0.1, 16.02±0.1, 17.12±0.1, 19.08±0.1, 21.00±0.1, 22.68±0.1, 23.48±0.1, 24.08±0.1, 26.52±0.1 and 28.08±0.1 degrees. The omeprazole sodium semihydrate is obtained by adding a raw material omeprazole sodium hydrate into an organic solvent, stirring same for 2-9 hours at a constant temperature of 25°C-60°C, and then filtering and drying same. The omeprazole sodium semihydrate of the present invention is high in purity, good in stability, will not easily agglomerate, and has good flowability, and has broader application prospects.

Omeprazole sodium semihydrate and preparation and preparation method thereof

The invention relates to a prasugrel hydrochloride ethanol solvate and a preparation method thereof The prasugrel hydrochloride ethanol solvate and the crystal thereof are defined on the aspects of X-ray powder diffraction pattern, diffraction angle 2 theta degrees, infrared spectroscopy and thermogravimetric curve The preparation method comprises the following steps of: dissolving prasugrel into a solvent, wherein the ratio of prasugrel to solvent in the solution is 008-02g/mL; adding hydrochloric acid; filtering; cooling and crystallizing the obtained solid in anhydrous ethanol, wherein the concentration of the initial solution is 01 to 03g/mL; and filtering the crystal mush, drying, thus obtaining the product X-ray diffraction (XRD) spectrograms and stereoscan photographs can prove that the crystallinity of the product is high, the granularity of the crystal is large, the surface of the crystal is smooth and clean, the filtering and drying speed is high, the efficiency of the preparation process is improved, and the solvate is beneficial to application to preparation of medicinal preparations

Prasugrel hydrochloride ethanol solvate and preparation method thereof

The invention relates to a preparation method of an argatroban intermediate esterified substance 4-methyl-2-ethyl piperidinecarboxylate. The preparation method comprises the following steps: adding a solvent, namely ethanol into a reaction kettle, putting a reactant, namely 4-methyl-2-piperidinecarboxylicacid hydrochloride into the reaction kettle, stirring to cool to (-5)-0 DEG C, maintaining the temperature, adding a catalyst, namely thionyl chloride, stirring to completely react until disappearance of raw material points is detected by virtue of a thin-layer chromatography, and carrying out vacuum reduced pressure concentration at 60 DEG C, so as to remove the solvent; and cooling the room temperature, adding dichloromethane, neutralizing reaction liquid by virtue of a 10% Na2CO3 solution, carrying out layered extraction, drying an organic solvent, and carrying out vacuum reduced pressure concentration at 50 DEG C on the organic solvent to remove the solvent, so as to obtain the esterified substance 4-methyl-2-ethyl piperidinecarboxylate. Mixed solvents including glacial acetic acid, ethanol and chloroform are replaced with single ethanol in a synthetic process, the reaction pressure is reduced, the catalyst thionyl chloride is low in cost, the operation is simple and convenient, the yield is substantially increased, and reaction solvents can be recycled, so that the preparation method is relatively beneficial to large-scale industrial production.

Baohong Hou

Papers

catena-Poly[[[(acetonitrile-κN)silver(I)]-μ-bis(pyrimidin-2-ylsulfanyl)methane-κ2N1:N1′] tetrafluoroborate]

Reply to “commentary on ‘effect of β-alanine and the solvent composition on the solubility of solvate of calcium d-pantothenate containing four molecules of methanol and one molecule of water (d-PC·4MeOH·1H2O)’”

Omeprazole sodium semihydrate and preparation and preparation method thereof

Prasugrel hydrochloride ethanol solvate and preparation method thereof

Preparation method of argatroban intermediate esterified substance 4-methyl-2-ethyl piperidinecarboxylate

Baohong Hou

Papers

catena-Poly[[[(acetonitrile-κN)silver(I)]-μ-bis­(pyrimidin-2-ylsulfan­yl)methane-κ2N1:N1′] tetra­fluoro­borate]

Reply to “commentary on ‘effect of β-alanine and the solvent composition on the solubility of solvate of calcium d-pantothenate containing four molecules of methanol and one molecule of water (d-PC·4MeOH·1H2O)’”

Omeprazole sodium semihydrate and preparation and preparation method thereof

Prasugrel hydrochloride ethanol solvate and preparation method thereof

Preparation method of argatroban intermediate esterified substance 4-methyl-2-ethyl piperidinecarboxylate

catena-Poly[[[(acetonitrile-κN)silver(I)]-μ-bis(pyrimidin-2-ylsulfanyl)methane-κ2N1:N1′] tetrafluoroborate]