Handbook of solubility data for pharmaceuticals , Handbook of solubility data for pharmaceuticals , کتابخانه دیجیتال جندی شاپور اهواز

http://chemistry-chemists.com/chemister/Spravochniki/handbook-of-solubility-data-for-pharmaceuticals-2010.pdf

Handbook of Solubility Data for Pharmaceuticals

As a novel class of porous crystalline materials, hydrogen-bonded organic frameworks (HOFs), self-assembled from organic or metal-organic building blocks through intermolecular hydrogen-bonding interactions, have attracted more and more attention. Over the past decade, a number of porous HOFs have been constructed through judicious selection of H-bonding motifs, which are further enforced by other weak intermolecular interactions such as π-π stacking and van der Waals forces and framework interpenetration. Since the H-bonds are weaker than coordinate and covalent bonds used for the construction of metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), HOFs have some unique features such as mild synthesis condition, solution processability, easy healing, and regeneration. These features enable HOFs to be a tunable platform for the construction of functional materials. Here, we review the H-bonding motifs used for constructing porous HOFs and highlight some of their applications, including gas separation and storage, chiral separation and structure determination, fluorescent sensing, heterogeneous catalysis, biological applications, proton conduction, photoluminescent materials, and membrane-based applications.

Hydrogen-Bonded Organic Frameworks as a Tunable Platform for Functional Materials.

The 31 P NMR spectra of triethylphosphine oxide (Et 3 PO) undergoes a shift upon interaction in solution with adjacent molecules. The oxygen of Et 3 PO is a strong electron donor and readily forms acid-base complexes with electron acceptors, with a consequent downfield shift in the 31 P NMR spectrum (Δδ ab ). We find that the 31 P NMR spectrum also is shifted downfield appreciably by van der Waals (largery dispersion force) interactions with solvents (Δδ d )

Spectral shifts in acid-base chemistry. II: Van der Waals contributions to acceptor numbers

An analytical model for spontaneous imbibition in fractal porous media including gravity

Poly(lactic acid) (PLA) is the most used biopolymer for food packaging applications. Several strategies have been made to improve PLA properties for extending its applications in the packaging field. Melt blending approaches are gaining considerable interest since they are easy, cost-effective and readily available processing technologies at the industrial level. With a similar melting temperature and high crystallinity, poly(hydroxybutyrate) (PHB) represents a good candidate to blend with PLA. The ability of PHB to act as a nucleating agent for PLA improves its mechanical resistance and barrier performance. With the dual objective to improve PLAPHB processing performance and to obtain stretchable materials, plasticizers are frequently added. Current trends to enhance PLA-PHB miscibility are focused on the development of composite and nanocomposites. PLA-PHB blends are also interesting for the controlled release of active compounds in the development of active packaging systems. This review explains the most relevant processing aspects of PLA-PHB based blends such as the influence of polymers molecular weight, the PLA-PHB composition as well as the thermal stability. It also summarizes the recent developments in PLA-PHB formulations with an emphasis on their performance with interest in the sustainable food packaging field. PLA-PHB blends shows highly promising perspectives for the replacement of traditional petrochemical based polymers currently used for food packaging.

On the Use of PLA-PHB Blends for Sustainable Food Packaging Applications

In this research, a new polymorph of florfenicol (form B) was discovered and successfully prepared. The new polymorph was characterized and identified by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) techniques. It was found that form A has lower melting temperature while higher fusion enthalpy. The solubility of both florfenicol polymorphs in methanol, 2-propanol, acetone, acetonitrile, ethanol, and ethyl acetate were experimentally determined from 278.15 to 318.15 K with a dynamic method. For all tested solvents, the solubility data of florfenicol form B are higher than those of form A. The modified Apelblat model, the NRTL model, and the λh model were adopted to calculate the solubility of florfenicol two forms with satisfactory correlation results. In addition, the dissolution thermodynamic properties of florfenicol form A and form B, including dissolution enthalpy, dissolution entropy, and Gibb’s dissolution energy in all tested solvents, were obtained. Combining the res...

Thermodynamic Properties of Form A and Form B of Florfenicol

Determination and correlation of solubility and thermodynamics of mixing of 4-aminobutyric acid in mono-solvents and binary solvent mixtures

The modified attachment energy model was employed to predict cefaclor dihydrate morphology Meanwhile, the mechanism and the effect of solvent and supersaturation on the crystal morphology were also proposed A molecular dynamics simulation was applied to investigate the interactions of cefaclor dihydrate crystal faces with the pure solvent model and the solution model The mechanism of solvent effects on the different faces was elaborated by discussing the surface structure and the adsorption of the crystal, while the effect of supersaturation was considered from the aspect of molecular recognition The radial distribution function analysis was introduced to explore the adsorption behaviors of solvent and solute molecules From the mean square displacement of solvent and solute molecules, the growth shape was affected by the solvent and solute diffusion capacity The results suggested that the morphology evolution is due to the subtle competition of the molecular adsorptions between the solute and solvent

Effects of solvent and supersaturation on crystal morphology of cefaclor dihydrate: a combined experimental and computer simulation study

There has been much interest in the role of solution chemistry in determining the polymorphic formation of organic crystals For convenience, the predominantly investigated systems are those that contain distinct building blocks among the polymorphs; in this work, an important drug excipient, D-mannitol (D-man), was selected as a case study, which represents a polymorphic system that only has the same building blocks By employing the Hirshfeld surface analysis and molecular dynamics (MD) simulations, D-man's crystal packing and the solvation nature in different solvents were studied on the molecular level The results suggest that there is a direct link between the solution speciation and crystal structure, and two distinct solvation modes were identified along with their impacts on nucleation This study indicates the significant role of solvation in determining D-man's nucleation and offers new insights into the research on systems that do not have distinct building blocks among the polymorphs

Baohong Hou

Papers

Thermodynamic Properties of Form A and Form B of Florfenicol

Determination and correlation of solubility and thermodynamics of mixing of 4-aminobutyric acid in mono-solvents and binary solvent mixtures

Effects of solvent and supersaturation on crystal morphology of cefaclor dihydrate: a combined experimental and computer simulation study

Revealing the roles of solvation in D-mannitol's polymorphic nucleation

Solution thermodynamics of tris-(2,4-ditert-butylphenyl)-phosphite in a series of pure solvents