Barbara Casadei

TL;DR: In this article, the authors investigated the sources of superoxide production (using inhibitors and substrates of a range of oxidases, RT-PCR, immunofluorescence, and immunoblotting) in tissue homogenates and isolated atrial myocytes from the right atrial appendage (RAA) of patients undergoing cardiac surgery (n=54 in sinus rhythm [SR] and 15 in AF).

TL;DR: Findings indicate that a myocardial NAD(P)H oxidase and, to a lesser extent, dysfunctional NOS contribute significantly to superoxide production in the fibrillating human atrial myocardium and may play an important role in the atrial oxidative injury and electrophysiological remodeling observed in patients with AF.

TL;DR: A novel mechanism by which intracellular Ca2+ is regulated in LV myocytes is uncovered and indicates that nNOS is an important determinant of basal contractility in the mammalian myocardium.

TL;DR: It is demonstrated for the first time that adiponectin improves the redox state in human vessels by restoring eNOS coupling, and a novel role of vascular oxidative stress in the regulation of adiponECTin expression in human perivascular adipose tissue is identified.

TL;DR: Perioperative statin therapy did not prevent postoperative atrial fibrillation or perioperative myocardial damage in patients undergoing elective cardiac surgery.