C
Craig A. Lygate
Researcher at University of Oxford
Publications - 118
Citations - 4448
Craig A. Lygate is an academic researcher from University of Oxford. The author has contributed to research in topics: Creatine & Creatine kinase. The author has an hindex of 34, co-authored 111 publications receiving 3971 citations. Previous affiliations of Craig A. Lygate include Wellcome Trust Centre for Human Genetics & John Radcliffe Hospital.
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Journal ArticleDOI
Cardiac Neuronal Nitric Oxide Synthase Isoform Regulates Myocardial Contraction and Calcium Handling
Claire E. Sears,Simon M. Bryant,Euan A. Ashley,Craig A. Lygate,Stevan Rakovic,Helen L. Wallis,Stefan Neubauer,Derek A. Terrar,Barbara Casadei +8 more
TL;DR: A novel mechanism by which intracellular Ca2+ is regulated in LV myocytes is uncovered and indicates that nNOS is an important determinant of basal contractility in the mammalian myocardium.
Journal ArticleDOI
Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.
Houman Ashrafian,Gabor Czibik,Mohamed Bellahcene,Dunja Aksentijevic,Anthony C. Smith,Sarah J. Mitchell,Sarah J. Mitchell,Michael S. Dodd,Jennifer A. Kirwan,Jonathan J. Byrne,Christian Ludwig,Henrik Isackson,Arash Yavari,Nicolaj B. Støttrup,Hussain Contractor,Thomas J. Cahill,Natasha Sahgal,Daniel R. Ball,Rune Isak Dupont Birkler,Iain P. Hargreaves,Daniel A. Tennant,John M. Land,Craig A. Lygate,Mogens Johannsen,Rajesh K. Kharbanda,Stefan Neubauer,Charles Redwood,Rafael de Cabo,Ismayil Ahmet,Mark I. Talan,Ulrich L. Günther,Alan J. Robinson,Mark R. Viant,Patrick J. Pollard,Damian J. Tyler,Hugh Watkins +35 more
TL;DR: It is proposed that clinically established fumarate derivatives activate the Nrf2 pathway and are readily testable cytoprotective agents.
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Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.
Tammie Bishop,Denis Gallagher,Alberto Pascual,Craig A. Lygate,J de Bono,L. G. Nicholls,Patricia Ortega-Sáenz,Henrik Oster,B. Wijeyekoon,A. I. Sutherland,A. Grosfeld,Julián Aragonés,Manuela Schneider,KV van Geyte,D. Teixeira,Antonio Diez-Juan,José López-Barneo,Keith M. Channon,Patrick H. Maxwell,Christopher W. Pugh,Alun M. Davies,Peter Carmeliet,Peter J. Ratcliffe +22 more
TL;DR: The observations suggest that the role of PHD3 in sympathoadrenal development extends beyond simple control of cell survival and organ mass, with functionalPHD3 being required for proper anatomical and physiological integrity of the system.
Journal ArticleDOI
nNOS Gene Deletion Exacerbates Pathological Left Ventricular Remodeling and Functional Deterioration After Myocardial Infarction
TL;DR: In this article, the authors investigated the role of the neuronal isoform of nitric oxide synthase (nNOS) in the regulation of basal and β-adrenergic inotropy in normal and chronically infarcted hearts.
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Fast, high-resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system.
Jürgen E. Schneider,Paul J. Cassidy,Craig A. Lygate,Damian J. Tyler,Frank Wiesmann,Stuart M. Grieve,Karen Hulbert,Kieran Clarke,Stefan Neubauer +8 more
TL;DR: To establish fast, high‐resolution in vivo cine magnetic resonance imaging (cine‐MRI) on a vertical 11.7‐T MR system and to investigate the stability of normal and failing mouse hearts in the vertical position.