Barbara U. Schraml

TL;DR: The diversity of DC subtypes found across tissues are reviewed and the current understanding of the tissue-specific functions of these cell types are discussed.

TL;DR: In this paper, the authors show that in early life, when the immune system develops, dendritic cells exhibit a dual hematopoietic origin and, like other myeloid and lymphoid cells, develop in waves.

TL;DR: It is suggested that the lymphoid lineage can generate cells with features of cDCs when myeloid cDC progenitors are impaired, and this study crosses Clec9a-Cre mice to Rosa-lox-STOP- lox-diphtheria toxin mice to reveal a previously unappreciated developmental heterogeneity of c DCs.

TL;DR: Investigating whether a complement-dependent immune adherence receptor is expressed on erythrocytes from the rainbow trout and the channel catfish suggests that differences exist in receptor distribution between two closely related species of fish, and a potentially homologous relationship in receptor expression, and possibility function, exist between two highly divergent species.

TL;DR: Some of the unique aspects of neonatal DCs that shape immune responses in early life are reviewed and whether the functional properties of neonnatal DCs could be exploited or manipulated to promote more effective vaccination in earlylife is speculated.