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Barton Holmquist
Researcher at Harvard University
Publications - 100
Citations - 4401
Barton Holmquist is an academic researcher from Harvard University. The author has contributed to research in topics: Alcohol dehydrogenase & Thermolysin. The author has an hindex of 41, co-authored 100 publications receiving 4354 citations. Previous affiliations of Barton Holmquist include Pennsylvania State University & Tufts Medical Center.
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A continuous spectrophotometric assay for angiotensin converting enzyme
TL;DR: Furanacryloyl tripeptides conforming to the known substrate specificity of the angiotensin converting enzyme (dipeptidyl carboxypeptidase, EC 3.4.15.1) have been employed to provide a continuous spectrophotometric assay for this peptidase in the visible region.
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Metal Substitutions and Inhibition of Thermolysin: Spectra of the Cobalt Enzyme
Barton Holmquist,Bert L. Vallee +1 more
TL;DR: It is concluded that the cobalt atom is coordinated in a distorted tetrahedral geometry, consistent both with those other cobalt-substituted zinc enzymes which exhibit similarly unusual properties as compared with Co(II) complex ions and with interpretations of x-ray structure analysis of native thermolysin.
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Thermolysin: a zinc metalloenzyme.
TL;DR: Metal analyses and inhibitor studies have shown that thermolysin, a neutral protease from B. thermoproteolyticus, is a zinc metalloenzyme.
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Neocarzinostatin: Spectral characterization and separation of a non-protein chromophore
TL;DR: Chromatographically purified neocarzinostatin exhibits absorption, fluorescence, magnetic circular dichroic and circular dichROic spectral characteristics above and below 300 nm atypical for a protein with its reported aminoacid composition, indicating the presence of a non-protein chromophore.