抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

where A represents the magnetic vector potential, is an integral of the hydromagnetic equations. This -integral made it possible to formulate a variational principle for the force-free magnetic fields. The integral expresses the fact that motions cannot transform a given field in an entirely arbitrary different field, if the conductivity of the medium isconsidered infinite. In this paper we shall show that the full set of hydromagnetic equations admit five more integrals, besides the energy integral, if dissipative processes are absent. These integrals, as we shall presently verify, are I2 =fbHvdV, (2)

Proceedings of the National Academy of Sciences

1. Introduction and overview 2. Film stress and substrate curvature 3. Stress in anisotropic and patterned films 4. Delamination and fracture 5. Film buckling, bulging and peeling 6. Dislocation formation in epitaxial systems 7. Dislocation interactions and strain relaxation 8. Equilibrium and stability of surfaces 9. The role of stress in mass transport.

Thin Film Materials: Stress, Defect Formation and Surface Evolution

Journal of Physics Condensed Matter: Preface

A drop hitting a solid surface can deposit, bounce, or splash. Splashing arises from the breakup of a fine liquid sheet that is ejected radially along the substrate. Bouncing and deposition depend crucially on the wetting properties of the substrate. In this review, we focus on recent experimental and theoretical studies, which aim at unraveling the underlying physics, characterized by the delicate interplay of not only liquid inertia, viscosity, and surface tension, but also the surrounding gas. The gas cushions the initial contact; it is entrapped in a central microbubble on the substrate; and it promotes the so-called corona splash, by lifting the lamella away from the solid. Particular attention is paid to the influence of surface roughness, natural or engineered to enhance repellency, relevant in many applications.

https://hal.archives-ouvertes.fr/hal-01398138/document

Drop Impact on a Solid Surface

We present a discrete treatment of adapted framed curves, parallel transport, and holonomy, thus establishing the language for a discrete geometric model of thin flexible rods with arbitrary cross section and undeformed configuration. Our approach differs from existing simulation techniques in the graphics and mechanics literature both in the kinematic description---we represent the material frame by its angular deviation from the natural Bishop frame---as well as in the dynamical treatment---we treat the centerline as dynamic and the material frame as quasistatic. Additionally, we describe a manifold projection method for coupling rods to rigid-bodies and simultaneously enforcing rod inextensibility. The use of quasistatics and constraints provides an efficient treatment for stiff twisting and stretching modes; at the same time, we retain the dynamic bending of the centerline and accurately reproduce the coupling between bending and twisting modes. We validate the discrete rod model via quantitative buckling, stability, and coupled-mode experiments, and via qualitative knot-tying comparisons.

/pdf/discrete-elastic-rods-1p72w8wrc9.pdf

Discrete elastic rods

1. Introduction 2. Three-dimensional elasticity I: RODS 3. Equations for elastic rods 4. Mechanics of the human hair 5. Rippled leaves, uncoiled springs II: PLATES 6. The equations for elastic plates 7. End effects in plate buckling 8. Finite amplitude buckling of a strip 9. Crumpled paper 10. Fractal buckling near edges III: SHELLS 11. Geometric rigidity of surfaces 12. Shells of revolution 13. The elastic torus 14. Spherical shell pushed by a wall Appendix A: Calculus of variations: a worked example Appendix B: Boundary and interior layers Appendix C: The geometry of helices Appendix D: Derivation of the plate equations by formal expansion from 3D elasticity

/pdf/elasticity-and-geometry-from-hair-curls-to-the-non-linear-3rmabdso6k.pdf

Elasticity and Geometry: From hair curls to the non-linear response of shells

Simulating human hair is recognized as one of the most difficult tasks in computer animation. In this paper, we show that the Kirchhoff equations for dynamic, inextensible elastic rods can be used for accurately predicting hair motion. These equations fully account for the nonlinear behavior of hair strands with respect to bending and twisting. We introduce a novel deformable model for solving them: each strand is represented by a Super-Helix, i.e., a piecewise helical rod which is animated using the principles of Lagrangian mechanics. This results in a realistic and stable simulation, allowing large time steps. Our second contribution is an in-depth validation of the Super-Helix model, carried out through a series of experiments based on the comparison of real and simulated hair motions. We show that our model efficiently handles a wide range of hair types with a high level of realism.

/pdf/super-helices-for-predicting-the-dynamics-of-natural-hair-3qqy3ixdvf.pdf

Super-helices for predicting the dynamics of natural hair

We present a continuum-based discrete model for thin threads of viscous fluid by drawing upon the Rayleigh analogy to elastic rods, demonstrating canonical coiling, folding, and breakup in dynamic simulations. Our derivation emphasizes space-time symmetry, which sheds light on the role of time-parallel transport in eliminating---without approximation---all but an O(n) band of entries of the physical system's energy Hessian. The result is a fast, unified, implicit treatment of viscous threads and elastic rods that closely reproduces a variety of fascinating physical phenomena, including hysteretic transitions between coiling regimes, competition between surface tension and gravity, and the first numerical fluid-mechanical sewing machine. The novel implicit treatment also yields an order of magnitude speedup in our elastic rod dynamics.

/pdf/discrete-viscous-threads-lq73jqc3hw.pdf

Discrete viscous threads

The buckling of a thin elastic film bound to a compliant substrate is studied: we analyze the different patterns that arise as a function of the biaxial residual compressive stress in the film. We first clarify the boundary conditions to be used at the interface between film and substrate. We carry out the linear stability analysis of the classical pattern made of straight stripes, and point out secondary instabilities leading to the formation of undulating stripes, varicose, checkerboard or hexagonal patterns. Straight stripes are found to be stable in a narrow window of load parameters only. We present a weakly nonlinear post-buckling analysis of these patterns: for equi-biaxial residual compression, straight wrinkles are never stable and square checkerboard patterns are found to be optimal just above threshold; for anisotropic residual compression, straight wrinkles are present above a primary threshold and soon become unstable with respect to undulating stripes. These results account for many of the previously published experimental or numerical results on this geometry.

Basile Audoly

Papers

Discrete elastic rods

Elasticity and Geometry: From hair curls to the non-linear response of shells

Super-helices for predicting the dynamics of natural hair

Discrete viscous threads

Buckling of a stiff film bound to a compliant substrate—Part I:: Formulation, linear stability of cylindrical patterns, secondary bifurcations