B
Bassel E. Sawaya
Researcher at Temple University
Publications - 92
Citations - 6100
Bassel E. Sawaya is an academic researcher from Temple University. The author has contributed to research in topics: Transcription (biology) & Transcription factor. The author has an hindex of 32, co-authored 85 publications receiving 5300 citations. Previous affiliations of Bassel E. Sawaya include Allegheny University of the Health Sciences & Drexel University.
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Journal Article
Retinoic Acid Modulates a Bimodal Effect on Cell Cycle Progression in Human Adult T-Cell Leukemia Cells
TL;DR: There is a correlation between cyclin/cyclin-dependent kinase activity and subunit complex formation with duration of drug exposure and a differential effect on cell cycle progression that was temporally related to length of ATRA exposure.
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High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons.
TL;DR: This is the first report to successfully measure the amount of Tat in neurons and places Tat as a key player involved in HIV-associated neurocognitive disorders.
Functional interaction between cyclin T/cdk9 and Puralpha determines the level of TNFalpha promoter activation by Tat in glial cells
TL;DR: A model is proposed which ascribes a bridging role for Puralpha in assembling Tat, cyclin T1, and cdk9 around the promoter region of TAR-negative genes such as TNFalpha, which is responsive to Tat activation.
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C/EBPβ regulates human immunodeficiency virus 1 gene expression through its association with cdk9
Giuseppe Mameli,Satish L. Deshmane,Mohammad Ghafouri,Jianqi Cui,Kenneth O Simbiri,Kamel Khalili,Ruma Mukerjee,Antonina Dolei,Shohreh Amini,Bassel E. Sawaya +9 more
TL;DR: The functional data show that co-transfection of C/EBPbeta and cdk9 leads to an increase in HIV-1 gene expression when compared to C/ eBPbeta alone, and that phosphorylated C/ EBPbeta may influence AIDS progression by increasing expression of HIV- 1 genes.
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p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes.
M. Saunders,M. B. Eldeen,L. Del Valle,Krzysztof Reiss,Francesca Peruzzi,G Mameli,Benjamin B. Gelman,Kamel Khalili,Shohreh Amini,Bassel E. Sawaya +9 more
TL;DR: The interplay between Tat and p73 may affect Tat contribution to apoptotic events in the brain, limiting its involvement in the neuropathology often observed in the brains of HIV-1 patients.