Bassel E. Sawaya

TL;DR: It is demonstrated that Tat causes rapid degradation of microtubule-associated protein 2 (MAP2) and the collapse of cytoskeletal filaments and may account for the loss of MAP2 and neuronal damage observed in the brain of AIDS patients with neurological dysfunctions.

TL;DR: The interaction of p53 with another key regulator, cdk9, which together with cyclin T1 forms the positive transcription elongation complex, p‐TEFb, is reported, pinpointing a novel mechanism by which p53 regulates the basal transcriptional machinery.

TL;DR: It is demonstrated that C/EBPbeta, whose activity is enhanced by a variety of cytokines during the course of viral infection, can stimulate basal- and Tat-mediated transcription of MCP-1 in human astrocytic cells and suggest that the delicate balance among the downstream regulatory proteins of several cytokines and immunomodulators can dictate the level of expression of chemoattractants.

TL;DR: The role of Nsp3, 4, and 6 in intracellular membrane rearrangement is focused on and the potential disruption of the central nervous system and the neurodegeneration which it could trigger is evaluated.

TL;DR: A role for p65 in regulating the ERVWE1 promoter and in TNFalpha-mediated induction of syncytin-1 in multiple sclerosis is illustrated.