B
Bassel E. Sawaya
Researcher at Temple University
Publications - 92
Citations - 6100
Bassel E. Sawaya is an academic researcher from Temple University. The author has contributed to research in topics: Transcription (biology) & Transcription factor. The author has an hindex of 32, co-authored 85 publications receiving 5300 citations. Previous affiliations of Bassel E. Sawaya include Allegheny University of the Health Sciences & Drexel University.
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Journal ArticleDOI
Transcriptional regulation of HIV-1 gene expression by p53
TL;DR: It is shown that over expression of p53 wild type prevented the phosphorylation of serine 2 in the carboxyl terminal domain (CTD) of RNA polymerase II, which stalled transcriptional elongation on the HIV-1 LTR leading to a significant reduction of HIV- 1 replication in primary microglia and astrocytes.
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Human immunodeficiency virus type 1 Tat prevents dephosphorylation of Sp1 by TCF-4 in astrocytes
TL;DR: Findings suggest that activity at the HIV-1 promoter is influenced by phosphorylation of Sp1, which is affected by Tat and DNA-PK, which may determine the level of viral gene transcription in human astrocytic cells.
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Association of p65 and C/EBPβ with HIV-1 LTR modulates transcription of the viral promoter
TL;DR: It is demonstrated that ectopic expression of p65 along with Tat increases p65 binding to HIV‐1 LTR, and that this increase correlates with enhanced HIV‐2 promoter activity, and a delicate balance of interaction between p65, C/EBPβ, and Tat can dictate the level of HIV‐ 1 LTR transcription.
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p73 Interacts with human immunodeficiency virus type 1 Tat in astrocytic cells and prevents its acetylation on lysine 28.
Shohreh Amini,G Mameli,Luis Del Valle,Anna Skowronska,Krzysztof Reiss,Benjamin B. Gelman,Martyn K. White,Kamel Khalili,Bassel E. Sawaya +8 more
TL;DR: P73 inhibited Tat stimulation of the HIV-1 promoter and prevented the interaction of Tat with cyclin T1 in vitro but not in vivo, suggesting possible new therapeutic approaches, using p73, for Tat-mediated AIDS pathogenesis.
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Identification of a cellular protein that binds to tat‐responsive element of TGFβ‐1 promoter in glial cells
Prakash Thatikunta,Bassel E. Sawaya,Lyudmilla Denisova,Crystina Cole,Galina Yusibova,Edward M. Johnson,Kamel Khalili,Shohreh Amini +7 more
TL;DR: A cellular protein is identified that interacts with the Tat‐responsive region located between nucleotides ‐323 to ‐453 of the regulatory sequence of the TGFβ‐1 promoter, consistent with previous reports on the cooperative action of Pur α and Tat in modulating other eukaryotic promoters.