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Bassel E. Sawaya
Researcher at Temple University
Publications - 92
Citations - 6100
Bassel E. Sawaya is an academic researcher from Temple University. The author has contributed to research in topics: Transcription (biology) & Transcription factor. The author has an hindex of 32, co-authored 85 publications receiving 5300 citations. Previous affiliations of Bassel E. Sawaya include Allegheny University of the Health Sciences & Drexel University.
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Journal ArticleDOI
A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: Potential impact on CTL epitopes
Alagarsamy Srinivasan,Velpandi Ayyavoo,Sundarasamy Mahalingam,Aarthi Kannan,Aarthi Kannan,Anne Boyd,Debduti Datta,Vaniambadi S. Kalyanaraman,Anthony D. Cristillo,Ronald G. Collman,Nelly Morellet,Bassel E. Sawaya,Ramachandran Murali +12 more
TL;DR: An in-depth analysis of genetic variation in Vpr using information from global HIV-1 isolates involving a total of 976 Vpr sequences suggests that amino acid polymorphisms may contribute to the immune escape of the virus.
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Involvement of miR-196a in HIV-associated neurocognitive disorders
Asen Bagashev,Ruma Mukerjee,Maryline Santerre,Fabiola Del Carpio-Cano,Jenny Shrestha,Ying Wang,Johnny J. He,Bassel E. Sawaya +7 more
TL;DR: The key role played by p73 and microRNA in Tat-treated neurons leading to their deregulation is highlighted and one of the pathways used by Tat to cause neuronal dysfunction that contributes to the development of HAND is deciphers mechanistically.
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Interaction between serine phosphorylated IRS-1 and β1-integrin affects the stability of neuronal processes
Jin Ying Wang,Elisa Gualco,Francesca Peruzzi,Bassel E. Sawaya,Giovanni Passiatore,Cezary Marcinkiewicz,Izabella Staniszewska,Pasquale Ferrante,Shohreh Amini,Kamel Khalili,Krzysztof Reiss +10 more
TL;DR: It is shown that β1‐integrin and pS‐IRS‐1 colocalize in PC12 cells and in primary cortical neurons and that IGF‐I counteracts TNFα‐mediated accumulation of pS •IRS •1–β1‐Integrin complexes supporting the stability of neuronal processes.
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Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis
TL;DR: Viruses take advantage of the non-metabolic effects of metabolic reprogramming, creating an anti-apoptotic environment and evading the immune system and other non-Metabolic effects can negatively affect cellular function.
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Potential use of RNA-dependent RNA polymerase (RdRp) inhibitors against SARS-CoV2 infection
TL;DR: Favipiravir and remdesivir, inhibitors of RNA-dependent RNA polymerase (RdRp) were recently suggested as a potential SARS-CoV2 inhibitors.