EASL-EORTC clinical practice guidelines : management of hepatocellular carcinoma

Since the publication of the American Association for the Study of Liver Diseases (AASLD) practice guidelines on the management of hepatocellular carcinoma (HCC) in 2005, new information has emerged that requires that the guidelines be updated. The full version of the new guidelines is available on the AASLD Web site at http://www.aasld.org/practiceguidelines/ Documents/Bookmarked%20Practice%20Guidelines/ HCCUpdate2010.pdf. Here, we briefly describe only new or changed recommendations.

/pdf/aasld-practice-guideline-management-of-hepatocellular-51bocalv0r.pdf

AASLD PRACTICE GUIDELINE Management of Hepatocellular Carcinoma: An Update

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admission. This proportion could already be greater in some parts of the country and may increase if referrals of cases of self-poisoning increase faster than the facilities for their assessment and management. The provision of social work and psychiatric expertise in casualty departments may be one means of preventing unnecessary medical admissions without risk to the patients. Dr Blake's and Dr Bramble's figures do not demonstrate, however, that any advantage would attach to medical teams taking over assessment from psychiatrists except that, by implication, assessments would be completed sooner by staff working on the ward full time. What the figures actually suggest is that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units (by 19°U), outpatients (by 5O°'), and referrals to social services (by 140o). So for house doctors to assess overdoses would provide no economy for the psychiatric or social services. The study does not tell us what the consequences would have been for the six patients who the psychiatrists would have admitted but to whom the house doctors would have offered outpatient appointments. E J SALTER

Vitamin D deficiency.

https://aasldpubs.onlinelibrary.wiley.com/doi/epdf/10.1002/hep.25762

The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

Evaluation of kinase-inhibitors nilotinib and everolimus against alveolar echinococcosis in vitro and in a mouse model

Chronic pancreatitis (CP) is a progressive infl ammatory process, which usually evolves over years into pancreatic cirrhosis, irrespective of endoscopic or surgical interventions, except autoimmune pancreatitis (reversed by steroids) or obstructive pancreatitis (relieved by removal of obstruction). The latter two conditions are not considered here, particularly because the typical progressive evolution of CP is lacking. In the diagnosis of CP two major problems need special attention: (1) staging, that is, differentiation between earlyversus late-stage CP and (2) etiology, specifi cally the impact of etiology on the evolution of CP from disease onset . Our presentation is focused primarily on these aspects and is based in particular on data from our prospective long-term study.

/pdf/do-the-diagnostic-criteria-differ-between-alcoholic-and-2w1lni64p4.pdf

Do the diagnostic criteria differ between alcoholic and nonalcoholic chronic pancreatitis

Should we screen for colorectal cancer in liver transplantation

https://www.journal-of-hepatology.eu/article/S0168-8278(05)00293-X/pdf

Is living donor liver transplantation cost-effective?

Pancreatic tumors are rare in children and adolescents. Here, we report the case of a 15-year-old boy who presented with a mixed acinar cell carcinoma/ductal adenocarcinoma with blastomatous components. He received multimodal treatment including various chemotherapy regimens and multistep surgery including liver transplantation. Introduction of FOLFIRINOX after relapse repeatedly achieved a durable metabolic and clinical response with good quality of life.

/pdf/successful-salvage-chemotherapy-with-folfirinox-for-199liys1ww.pdf

Successful Salvage Chemotherapy with FOLFIRINOX for Recurrent Mixed Acinar Cell Carcinoma and Ductal Adenocarcinoma of the Pancreas in an Adolescent Patient.

Beat Müllhaupt

Papers

Evaluation of kinase-inhibitors nilotinib and everolimus against alveolar echinococcosis in vitro and in a mouse model

Do the diagnostic criteria differ between alcoholic and nonalcoholic chronic pancreatitis

Should we screen for colorectal cancer in liver transplantation

Is living donor liver transplantation cost-effective?

Successful Salvage Chemotherapy with FOLFIRINOX for Recurrent Mixed Acinar Cell Carcinoma and Ductal Adenocarcinoma of the Pancreas in an Adolescent Patient.