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Beat Müllhaupt
Researcher at University of Zurich
Publications - 289
Citations - 17086
Beat Müllhaupt is an academic researcher from University of Zurich. The author has contributed to research in topics: Hepatitis C & Liver transplantation. The author has an hindex of 55, co-authored 258 publications receiving 14656 citations.
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Journal ArticleDOI
The Model for End-Stage Liver Disease Allocation System for Liver Transplantation Saves Lives, but Increases Morbidity and Cost: A Prospective Outcome Analysis
Philipp Dutkowski,Christian E. Oberkofler,Markus Béchir,Beat Müllhaupt,Andreas Geier,Dimitri A. Raptis,Pierre-Alain Clavien +6 more
TL;DR: The postoperative course appears more difficult in the MELD era with increased financial burden, but reasonable patient and graft survival, and the inevitable price to balance justice and utility in liver graft allocation.
Journal ArticleDOI
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development
Yannick Boege,Mohsen Malehmir,Marc E. Healy,Kira Bettermann,Anna Lorentzen,Mihael Vucur,Akshay K. Ahuja,Friederike Böhm,Joachim C. Mertens,Yutaka Shimizu,Lukas Frick,Caroline Remouchamps,Karun Mutreja,Thilo Kähne,Devakumar Sundaravinayagam,Monika Julia Wolf,Hubert Rehrauer,Christiane Koppe,Tobias Speicher,Susagna Padrissa-Altés,Renaud Maire,Jörn M. Schattenberg,Ju-Seong Jeong,Lei Liu,Stefan Zwirner,Stefan Zwirner,RJ Boger,Norbert Hüser,Roger J. Davis,Beat Müllhaupt,Holger Moch,Henning Schulze-Bergkamen,Pierre-Alain Clavien,Sabine Werner,Lubor Borsig,Sanjiv A. Luther,Philipp J. Jost,Ricardo Weinlich,Kristian Unger,Axel Behrens,Laura K. Hillert,Christopher P. Dillon,Michela Di Virgilio,David Wallach,Emmanuel Dejardin,Lars Zender,Lars Zender,Michael Naumann,Henning Walczak,Douglas R. Green,Massimo Lopes,Inna N. Lavrik,Tom Luedde,Mathias Heikenwalder,Mathias Heikenwalder,Achim Weber +55 more
TL;DR: This work mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and replication-associated DNA damage through DNA damage-sensing mechanism in hepatocytes.
Journal ArticleDOI
Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes
Ewa Terczyńska-Dyla,Stéphanie Bibert,Francois H.T. Duong,Francois H.T. Duong,Ilona Krol,Ilona Krol,Sanne Jørgensen,Emilie Collinet,Zoltán Kutalik,Zoltán Kutalik,Vincent Aubert,Andreas Cerny,Laurent Kaiser,Raffaele Malinverni,Alessandra Mangia,Darius Moradpour,Beat Müllhaupt,Francesco Negro,Rosanna Santoro,David Semela,Nasser Semmo,Markus H. Heim,Markus H. Heim,Pierre-Yves Bochud,Rune Hartmann +24 more
TL;DR: Evidence supporting a role for the active IFNλ4 protein as the driver of high hepatic ISG expression as well as the cause of poor HCV clearance is provided.
Journal ArticleDOI
Performance of Serum microRNAs -122, -192 and -21 as Biomarkers in Patients with Non-Alcoholic Steatohepatitis.
Philip P. Becker,Monika Rau,Johannes Schmitt,Carolin Malsch,Christian Hammer,Heike Bantel,Beat Müllhaupt,Andreas Geier +7 more
TL;DR: Candidates for a combined model of miRNAs and CK18-Asp396 levels relevant as a promising expansion for diagnosis and in turn treatment of NASH are defined.
Journal ArticleDOI
Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal
Johannes Schmitt,Bo Kong,Bruno Stieger,Oliver Tschopp,Simon M. Schultze,Monika Rau,Achim Weber,Beat Müllhaupt,Grace L. Guo,Andreas Geier +9 more
TL;DR: Organ‐specific Fxr knockout mice were used to further investigate the influence of farnesoid X receptor FXR in lipogenesis and bile acids are involved in the regulation of triglyceride‐, cholesterol‐homoeostasis and fat absorption.