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Beat Müllhaupt
Researcher at University of Zurich
Publications - 289
Citations - 17086
Beat Müllhaupt is an academic researcher from University of Zurich. The author has contributed to research in topics: Hepatitis C & Liver transplantation. The author has an hindex of 55, co-authored 258 publications receiving 14656 citations.
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Journal ArticleDOI
Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis.
Johannes Noe,Gerd A. Kullak-Ublick,Wolfram Jochum,Bruno Stieger,Reinhold Kerb,Michael Haberl,Beat Müllhaupt,Peter J. Meier,Christiane Pauli-Magnus +8 more
TL;DR: By combining functional in-vitro characterization with immunohistochemical detection of variant BSEP, this work provides direct evidence for the role of ABCB11 mutations in the pathogenesis of different forms of intrahepatic cholestasis.
Journal ArticleDOI
Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection
Stefan Zeuzem,Tarik Asselah,Peter W Angus,Jean-Pierre Zarski,Dominique Larrey,Beat Müllhaupt,Edward Gane,Marcus Schuchmann,Ansgar W. Lohse,Stanislas Pol,Jean-Pierre Bronowicki,Stuart K. Roberts,Keikawus Arastéh,Fabien Zoulim,Markus H. Heim,Jerry O. Stern,George Kukolj,Gerhard Nehmiz,Carla Haefner,Wulf Otto Boecher +19 more
TL;DR: The combination of the protease inhibitor BI 201335, the polymerase inhibitors BI 207127, and ribavirin has rapid and strong activity against HCV genotype-1 and did not cause serious or severe adverse events.
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Patterns of Resistance-Associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-Acting Antivirals
Julia Dietz,Simone Susser,Johannes Vermehren,Kai-Henrik Peiffer,Georgios Grammatikos,Annemarie Berger,Peter Ferenci,Maria Buti,Beat Müllhaupt,Béla Hunyady,Holger Hinrichsen,Stefan Mauss,Jörg Petersen,Peter Buggisch,G Felten,Dietrich Hüppe,G Knecht,Thomas A. Lutz,Eckart Schott,Christoph P. Berg,Ulrich Spengler,Thomas von Hahn,Thomas Berg,Stefan Zeuzem,Christoph Sarrazin +24 more
TL;DR: RASs in NS3, NS5A, and NS5B among patients failed by DAA therapy varied with the HCV genotype and subtype, and the different drug classes, and these findings might be used to select salvage therapies.
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Golgi phosphoprotein 2 (GOLPH2) expression in liver tumors and its value as a serum marker in hepatocellular carcinomas
Marc-Oliver Riener,Frank Stenner,Heike Liewen,Christopher Soll,Stefan Breitenstein,Bernhard C. Pestalozzi,Panagiotis Samaras,Nicole Probst-Hensch,Claus Hellerbrand,Beat Müllhaupt,Pierre-Alain Clavien,Marcus Bahra,Peter Neuhaus,Peter J. Wild,Florian R. Fritzsche,Holger Moch,Wolfram Jochum,Glen Kristiansen +17 more
TL;DR: In patients with hepatitis C, serial ELISA measurements in the course of the disease appear to be a promising complementary serum marker in the surveillance of HCC.
Journal ArticleDOI
Impact of donor and recipient IL28B rs12979860 genotypes on hepatitis C virus liver graft reinfection
Christian M. Lange,Christian M. Lange,Darius Moradpour,Alexandra Doehring,Hans-Anton Lehr,Beat Müllhaupt,Stéphanie Bibert,Pierre-Yves Bochud,Antonino A,Manuel Pascual,Harald Farnik,Y. Shi,Wolf O. Bechstein,C. Moench,Martin-Leo Hansmann,Christoph Sarrazin,Jörn Lötsch,Stefan Zeuzem,Wolf-Peter Hofmann +18 more
TL;DR: Evidence is provided for a dominant, but not exclusive impact of the donor rather than the recipient IL28B genetic background on the natural course and treatment outcome of HCV liver graft reinfection.