B
Beate Michely
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 4
Citations - 904
Beate Michely is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Dilated cardiomyopathy & Cardiomyopathy. The author has an hindex of 4, co-authored 4 publications receiving 845 citations. Previous affiliations of Beate Michely include Humboldt University of Berlin.
Papers
More filters
Journal ArticleDOI
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy
Brenda Gerull,Brenda Gerull,Arnd Heuser,Arnd Heuser,Thomas Wichter,Matthias Paul,Craig T. Basson,Deborah A. McDermott,Bruce B. Lerman,Steve M Markowitz,Patrick T. Ellinor,Calum A. MacRae,Stefan Peters,Katja S. Grossmann,Beate Michely,Beate Michely,Sabine Sasse-Klaassen,Walter Birchmeier,Rainer Dietz,Günter Breithardt,Eric Schulze-Bahr,Ludwig Thierfelder,Ludwig Thierfelder +22 more
TL;DR: In two kindreds with ARVC, disease was incompletely penetrant in most carriers of PKP2 mutations, and the identified heterozygous mutations inPKP2, which encodes plakophilin-2, an essential armadillo-repeat protein of the cardiac desmosome.
Journal ArticleDOI
Stress-induced dilated cardiomyopathy in a knock-in mouse model mimicking human titin-based disease.
Michael Gramlich,Beate Michely,Christian Krohne,Arnd Heuser,Bettina Erdmann,Sabine Klaassen,Bryan D. Hudson,Manuela Magarin,Florian Kirchner,Mihail Todiras,Henk Granzier,Siegfried Labeit,Ludwig Thierfelder,Brenda Gerull +13 more
TL;DR: A titin knock-in mouse model mimics typical features of human dilated cardiomyopathy and may further the understanding of how titin mutations perturb cardiac function and remodel the heart.
Journal ArticleDOI
A novel locus for dilated cardiomyopathy, diffuse myocardial fibrosis, and sudden death on chromosome 10q25-26.
Patrick T. Ellinor,Sabine Sasse-Klaassen,Susanne Probst,Brenda Gerull,Jordan T. Shin,Andrea Toeppel,Arnd Heuser,Beate Michely,Danita M. Yoerger,Bong Seok Song,Bernhard Pilz,Gregor Krings,Bruce Coplin,Peter Lange,G. William Dec,Hans Christian Hennies,Ludwig Thierfelder,Calum A. MacRae +17 more
TL;DR: Genome-wide linkage analysis identified a novel locus for an inherited form of dilated cardiomyopathy that is characterized by diffuse myocardial fibrosis and sudden death on chromosome 10q25.3-q26.13.
Journal ArticleDOI
Correction: Corrigendum: Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy
Brenda Gerull,Arnd Heuser,Thomas Wichter,Matthias Paul,Craig T. Basson,Deborah A. McDermott,Bruce B. Lerman,Steve M Markowitz,Patrick T. Ellinor,Calum A. MacRae,Stefan Peters,K S Grossman,Beate Michely,Sabine Sasse-Klaassen,M Birchmeier,Rainer Dietz,Günter Breithardt,Eric Schulze-Bahr,Ludwig Thierfelder +18 more
TL;DR: This work aims to provide a systematic literature review of the determinants of cell reprograming and its applications in medicine and biomedical research.