T
Thomas Wichter
Researcher at University of Münster
Publications - 152
Citations - 14849
Thomas Wichter is an academic researcher from University of Münster. The author has contributed to research in topics: Right ventricular cardiomyopathy & Ventricular tachycardia. The author has an hindex of 59, co-authored 152 publications receiving 13654 citations.
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Journal ArticleDOI
Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia Proposed Modification of the Task Force Criteria
Frank I. Marcus,William J. McKenna,Duane L. Sherrill,Cristina Basso,Barbara Bauce,David A. Bluemke,Hugh Calkins,Domenico Corrado,Moniek G.P.J. Cox,James P. Daubert,Guy Fontaine,Kathleen Gear,Richard N.W. Hauer,Andrea Nava,Michael H. Picard,Nikos Protonotarios,Jeffrey E. Saffitz,Danita M. Yoerger Sanborn,Jonathan S. Steinberg,Harikrishna Tandri,Gaetano Thiene,Jeffrey A. Towbin,Adalena Tsatsopoulou,Thomas Wichter,Wojciech Zareba +24 more
TL;DR: Modifications of the Task Force Criteria for the clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia represent a working framework to improve the diagnosis and management of this condition.
Journal ArticleDOI
Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia
Frank I. Marcus,William J. McKenna,Duane L. Sherrill,Cristina Basso,Barbara Bauce,David A. Bluemke,Hugh Calkins,Domenico Corrado,Moniek G.P.J. Cox,James P. Daubert,Guy Fontaine,Kathleen Gear,Richard N.W. Hauer,Andrea Nava,Michael H. Picard,Nikos Protonotarios,Jeffrey E. Saffitz,Danita M. Yoerger Sanborn,Jonathan S. Steinberg,Harikrishna Tandri,Gaetano Thiene,Jeffrey A. Towbin,Adalena Tsatsopoulou,Thomas Wichter,Wojciech Zareba +24 more
TL;DR: The criteria for the clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia have been modified to incorporate new knowledge and technology to improve diagnostic sensitivity, but with the important requisite of maintaining diagnostic specificity.
Journal ArticleDOI
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy
Brenda Gerull,Brenda Gerull,Arnd Heuser,Arnd Heuser,Thomas Wichter,Matthias Paul,Craig T. Basson,Deborah A. McDermott,Bruce B. Lerman,Steve M Markowitz,Patrick T. Ellinor,Calum A. MacRae,Stefan Peters,Katja S. Grossmann,Beate Michely,Beate Michely,Sabine Sasse-Klaassen,Walter Birchmeier,Rainer Dietz,Günter Breithardt,Eric Schulze-Bahr,Ludwig Thierfelder,Ludwig Thierfelder +22 more
TL;DR: In two kindreds with ARVC, disease was incompletely penetrant in most carriers of PKP2 mutations, and the identified heterozygous mutations inPKP2, which encodes plakophilin-2, an essential armadillo-repeat protein of the cardiac desmosome.
Journal ArticleDOI
Long-Term Prognosis of Individuals With Right Precordial ST-Segment–Elevation Brugada Syndrome
Lars Eckardt,Vincent Probst,Jeroen P.P. Smits,Eric Schulze Bahr,Christian Wolpert,Rainer Schimpf,Thomas Wichter,Pierre Boisseau,Achim Heinecke,Günter Breithardt,Martin Borggrefe,Herve LeMarec,Dirk Böcker,Arthur A.M. Wilde +13 more
TL;DR: A very low incidence of severe arrhythmic events, particularly in asymptomatic individuals, was found during follow-up and programmed electrical stimulation showed very little accuracy in predicting outcome.
Journal ArticleDOI
Age- and Training-Dependent Development of Arrhythmogenic Right Ventricular Cardiomyopathy in Heterozygous Plakoglobin-Deficient Mice
Paulus Kirchhof,Larissa Fabritz,Melanie Zwiener,Henning Witt,Michael Schäfers,Stephan Zellerhoff,Matthias Paul,Timur Athai,Karl-Heinz Hiller,Hideo Baba,Günter Breithardt,Patricia Ruiz,Thomas Wichter,Bodo Levkau +13 more
TL;DR: A functional role for plakoglobin and training in the development of ARVC is suggested, as Manifestation of the phenotype is accelerated by endurance training.