C
Craig T. Basson
Researcher at Novartis
Publications - 114
Citations - 11080
Craig T. Basson is an academic researcher from Novartis. The author has contributed to research in topics: Carney complex & Holt–Oram syndrome. The author has an hindex of 45, co-authored 112 publications receiving 10415 citations. Previous affiliations of Craig T. Basson include Oregon State University & Brigham and Women's Hospital.
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Journal ArticleDOI
Congenital Heart Disease Caused by Mutations in the Transcription Factor NKX2-5
Jean-Jacques Schott,D. Woodrow Benson,Craig T. Basson,William E. Pease,G. Michael Silberbach,Jeffrey P. Moak,Barry J. Maron,Christine E. Seidman,Jonathan G. Seidman +8 more
TL;DR: Data indicate that NKX2-5 is important for regulation of septation during cardiac morphogenesis and for maturation and maintenance of atrioventricular node function throughout life.
Journal ArticleDOI
Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome.
Craig T. Basson,D. R. Bachinsky,R. C. Lin,Tatjana Levi,Jacob A. Elkins,Johanna Soults,David Grayzel,Elena Kroumpouzou,Thomas A. Traill,Janine M. LeBlanc-Straceski,Janine M. LeBlanc-Straceski,Beatrice Renault,Raju Kucherlapati,Jonathan G. Seidman,Christine E. Seidman +14 more
TL;DR: It is concluded that TBX5 is critical for limb and heart development and suggest that haploinsufficiency ofTBX5 causes Holt-Oram syndrome.
Journal ArticleDOI
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy
Brenda Gerull,Brenda Gerull,Arnd Heuser,Arnd Heuser,Thomas Wichter,Matthias Paul,Craig T. Basson,Deborah A. McDermott,Bruce B. Lerman,Steve M Markowitz,Patrick T. Ellinor,Calum A. MacRae,Stefan Peters,Katja S. Grossmann,Beate Michely,Beate Michely,Sabine Sasse-Klaassen,Walter Birchmeier,Rainer Dietz,Günter Breithardt,Eric Schulze-Bahr,Ludwig Thierfelder,Ludwig Thierfelder +22 more
TL;DR: In two kindreds with ARVC, disease was incompletely penetrant in most carriers of PKP2 mutations, and the identified heterozygous mutations inPKP2, which encodes plakophilin-2, an essential armadillo-repeat protein of the cardiac desmosome.
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Genetic Basis for Congenital Heart Defects: Current Knowledge A Scientific Statement From the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young
Mary Ella M Pierpont,Craig T. Basson,D. Woodrow Benson,Bruce D. Gelb,Therese M. Giglia,Elizabeth Goldmuntz,Glenn McGee,Craig Sable,Deepak Srivastava,Catherine L. Webb +9 more
TL;DR: It is anticipated that this summary will update a wide range of medical personnel about the genetic aspects of congenital heart disease and will encourage an interdisciplinary approach to the child and adult with congenitals heart disease.
Journal ArticleDOI
The evolving role of statins in the management of atherosclerosis.
TL;DR: Clinical and experimental evidence indicates that the beneficial actions of statins occur rapidly and yield potentially clinically important anti-ischemic effects as early as one month after commencement of therapy.