Béatrice Térouanne

TL;DR: The ubiquitous presence of endocrine disruptors in the environment and the increased incidence of neonatal genital malformation support the hypothesis that disturbed male sexual differentiation may in some cases be caused by increased exposure to environmental xenoestrogens and/or antiandrogens.

TL;DR: It is demonstrated for the first time the intracellular dynamics of the hormone-dependent trafficking of AR in a single living cell and GFP-AR conserves the functional properties of the AR.

TL;DR: Evidence is provided that several phenyl derivatives present both estrogenic and antiandrogenic activity and these environmental chemicals may have a negative impact on androgen action during fetal and post-natal life.

TL;DR: Hsp90 inactivation impedes interaction of androgen-bound GFP-NLS-AR with nuclear components and inhibits transcriptional activity, and it is concluded that hsp90s are required for the acquisition of active conformation in agonist-bound AR to regulate nuclear transfer, nuclear matrix binding, and transcriptionalactivity.

TL;DR: Results demonstrate that OC endocrine activities in vivo probably result from direct and specific binding to the AR ligand-binding domain, and support the hypothesis that the recent increase in the incidence of male sexual disorders could be due to long exposure to ubiquitous OC pesticides found in the environment.