J
Jean-Claude Nicolas
Researcher at French Institute of Health and Medical Research
Publications - 138
Citations - 5112
Jean-Claude Nicolas is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Receptor & Androgen receptor. The author has an hindex of 39, co-authored 138 publications receiving 4956 citations. Previous affiliations of Jean-Claude Nicolas include University of Montpellier.
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Reporter cell lines to study the estrogenic effects of xenoestrogens.
Patrick Balaguer,Fabienne François,Franck Comunale,Hélène Fenet,Anne-Marie Boussioux,Michel Pons,Jean-Claude Nicolas,Claude Casellas +7 more
TL;DR: Four cellular models were established as tools to check the estrogenic activities of several potential xenoestrogens and to detect estrogenic activity in wastewater sewage treatment effluents and these models, which express the endogenous estrogen receptor alpha, were tested.
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Environmental xenoestrogens, antiandrogens and disorders of male sexual differentiation.
Charles Sultan,Patrick Balaguer,Béatrice Térouanne,Virginie Georget,Françoise Paris,Claire Jeandel,Serge Lumbroso,Jean-Claude Nicolas +7 more
TL;DR: The ubiquitous presence of endocrine disruptors in the environment and the increased incidence of neonatal genital malformation support the hypothesis that disturbed male sexual differentiation may in some cases be caused by increased exposure to environmental xenoestrogens and/or antiandrogens.
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Trafficking of the androgen receptor in living cells with fused green fluorescent protein-androgen receptor.
Virginie Georget,J M Lobaccaro,Béatrice Térouanne,P. Mangeat,Jean-Claude Nicolas,Charles Sultan +5 more
TL;DR: It is demonstrated for the first time the intracellular dynamics of the hormone-dependent trafficking of AR in a single living cell and GFP-AR conserves the functional properties of the AR.
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Mapping EBNA-1 domains involved in binding to metaphase chromosomes.
Vincent Maréchal,Axelle Dehee,Roxane Chikhi-Brachet,Tristan Piolot,Maite Coppey-Moisan,Jean-Claude Nicolas +5 more
TL;DR: The results show that binding to metaphase chromosomes is a common property of EBV and HVP EBNA-1, fused to a variant of the green fluorescent protein and in agreement with the anchorage model, two of these domains mapped to a region that has been previously demonstrated to be required for the long-term persistence of OriP-containing plasmids.
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Phenylphenols, biphenols, bisphenol-A and 4-tert-octylphenol exhibit α and β estrogen activities and antiandrogen activity in reporter cell lines
Françoise Paris,Patrick Balaguer,Béatrice Térouanne,Nadège Servant,Caroline Lacoste,Jean-Pierre Cravedi,Jean-Claude Nicolas,Charles Sultan +7 more
TL;DR: Evidence is provided that several phenyl derivatives present both estrogenic and antiandrogenic activity and these environmental chemicals may have a negative impact on androgen action during fetal and post-natal life.