B
Belinda Phipson
Researcher at Royal Children's Hospital
Publications - Â 58
Citations - Â 28640
Belinda Phipson is an academic researcher from Royal Children's Hospital. The author has contributed to research in topics: Bioconductor & Progenitor cell. The author has an hindex of 27, co-authored 51 publications receiving 18485 citations. Previous affiliations of Belinda Phipson include University of Melbourne & Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
Gene set enrichment analysis for genome-wide DNA methylation data.
TL;DR: GOmeth and GOregion as discussed by the authors are new methods for performing unbiased gene set testing following differential methylation analysis, which are publicly available in the missMethyl Bioconductor R package.
Journal ArticleDOI
Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia
N Narayan,N Narayan,N Narayan,L Morenos,Belinda Phipson,Simon N. Willis,Simon N. Willis,Gabriela Brumatti,Gabriela Brumatti,Stefanie Eggers,Najoua Lalaoui,Najoua Lalaoui,Lauren M Brown,Lauren M Brown,Hansen J. Kosasih,Ray C Bartolo,L Zhou,Daniel Catchpoole,Daniel Catchpoole,Daniel Catchpoole,Richard Saffery,Richard Saffery,Alicia Oshlack,Gregory J. Goodall,Gregory J. Goodall,Paul G Ekert,Paul G Ekert +26 more
TL;DR: A novel dose-dependent role for miR-155 in the regulation of AML is described, which may have important therapeutic implications and is described as " novel" in the context of acute myeloid leukaemia.
Journal ArticleDOI
Gene length and detection bias in single cell RNA sequencing protocols.
TL;DR: The finding that scRNA-seq datasets that have been sequenced using a full-length transcript protocol exhibit gene length bias akin to bulk RNA-seq data is found, and it is illustrated that full- length and UMI data can be combined to reveal the underlying biology influencing expression of mESCs.
Posted ContentDOI
Gene set enrichment analysis for genome-wide DNA methylation data
Jovana Maksimovic,Jovana Maksimovic,Alicia Oshlack,Alicia Oshlack,Belinda Phipson,Belinda Phipson +5 more
TL;DR: GOmeth and GOregion are new methods for performing unbiased gene set testing following differential methylation analysis and are publicly available in the missMethyl Bioconductor R package.
Journal ArticleDOI
Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor
Choon Boon Sim,Belinda Phipson,Belinda Phipson,Mark Ziemann,Mark Ziemann,Mark Ziemann,Haloom Rafehi,Haloom Rafehi,Richard J. Mills,Kevin I. Watt,Kwaku Dad Abu-Bonsrah,Kwaku Dad Abu-Bonsrah,Ravi K.R. Kalathur,Holly K. Voges,Holly K. Voges,Doan T. Dinh,Menno ter Huurne,CĂ©line Vivien,Antony Kaspi,Antony Kaspi,Harikrishnan Kaipananickal,Harikrishnan Kaipananickal,Alejandro Hidalgo,Alejandro Hidalgo,Leanne M. D. Delbridge,Leanne M. D. Delbridge,Rebecca L. Robker,Paul Gregorevic,Cristobal G. dos Remedios,Cristobal G. dos Remedios,Sean Lal,Adam T. Piers,Igor E. Konstantinov,David A. Elliott,David A. Elliott,Assam El-Osta,Alicia Oshlack,Alicia Oshlack,Alicia Oshlack,James E. Hudson,James E. Hudson,Enzo R. Porrello +41 more
TL;DR: In this article, the progesterone receptor was identified as a key mediator of sexdependent transcriptional programs during cardiomyocyte maturation, and functional validation studies of sex steroids implicated in cardiac maturation were performed in human pluripotent stem cell-derived cardiac organoids and mice.