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Benita S. Katzenellenbogen
Researcher at University of Illinois at Urbana–Champaign
Publications - 403
Citations - 41240
Benita S. Katzenellenbogen is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Estrogen receptor & Estrogen. The author has an hindex of 113, co-authored 394 publications receiving 39585 citations. Previous affiliations of Benita S. Katzenellenbogen include Dartmouth College & University of Cincinnati.
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The nature of the ligand-binding pocket of estrogen receptor alpha and beta: The search for subtype-selective ligands and implications for the prediction of estrogenic activity
TL;DR: A number of ligands are identified that show pronounced ER subtype selectivity and highlight the eclectic structure–activity relationships of estrogens and the challenges inherent in developing computational methods for the prediction of estrogenic activity.
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Repression of endogenous estrogen receptor activity in MCF-7 human breast cancer cells by dominant negative estrogen receptors
TL;DR: The data suggest that S554fs in particular is a reasonable candidate for studies designed to use a dominant negative ER to inhibit the estrogen- and tamoxifen-stimulated growth of human breast cancer cells.
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Regulation of Prothymosin α Gene Expression by Estrogen in Estrogen Receptor-Containing Breast Cancer Cells via Upstream Half-Palindromic Estrogen Response Element Motifs
TL;DR: Prothymosin α (PTα), a protein associated with cell proliferation and chromatin remodeling, and found to selectively enhance ER transcriptional activity by interacting with a repressor of ER activity, is shown to be a primary response gene to estrogen.
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Analogs of Methyl-Piperidinopyrazole (MPP): Antiestrogens with Estrogen Receptor α Selective Activity
Hai-Bing Zhou,Kathryn E. Carlson,Fabio Stossi,Benita S. Katzenellenbogen,John A. Katzenellenbogen +4 more
TL;DR: To remove the possibility that metabolic cleavage of the BSC in MPP would regenerate MPT, the N-piperidinylethoxy moiety is replaced with an N- piperidinylpropyl group, giving MPrP, which retains the high ERalpha-selective binding affinity and antagonist potency of MPP.
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Some properties of silkmoth moulting gel and moulting fluid
TL;DR: Proteolytic activity appears in the moulting fluid at the beginning of the last week of the pharate adult stage and shows a time-activity profile that correlates well with the rate of digestion of pupal endocuticle, suggesting that as adult development proceeds, the fluid becomes enriched in dialysable components.