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Benita S. Katzenellenbogen
Researcher at University of Illinois at Urbana–Champaign
Publications - 403
Citations - 41240
Benita S. Katzenellenbogen is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Estrogen receptor & Estrogen. The author has an hindex of 113, co-authored 394 publications receiving 39585 citations. Previous affiliations of Benita S. Katzenellenbogen include Dartmouth College & University of Cincinnati.
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Determinants for the repression of estrogen receptor transcriptional activity by ligand-occupied progestin receptors.
TL;DR: A number of parameters which are naturally varied in vivo, such as the sequence of PR DNA binding sites and the PR A:PR B ratio, can dramatically alter the repression of ER activity by liganded PR, and may explain the differential affects of progestin-occupied PR on the expression of different estrogen regulated genes.
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A MicroRNA196a2* and TP63 Circuit Regulated by Estrogen Receptor-α and ERK2 that Controls Breast Cancer Proliferation and Invasiveness Properties
TL;DR: The findings reveal a tumor suppressive role of hsa-miR-196a2* through regulation of TP63 by ERα and/or ERK2 signaling and might provide a potential tumor-suppressive strategy to alleviate the aggressive behavior and poor prognosis of some ER α-positive as well as many ERα-negative breast cancers.
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Stilbestrols and stilbestrol derivatives: estrogenic potency and temporal relationships between estrogen receptor binding and uterine growth.
Benita S. Katzenellenbogen,Harriet S. Iwamoto,Daniel F. Heiman,Nancy C. Lan,John A. Katzenellenbogen +4 more
TL;DR: The weak activity of DMS appears to be due to its short duration of interaction with receptor, and conversion to the methyl ether prolongs nuclear receptor occupancy and increases its biological potency, while etherification of the more active estrogen, DES, diminishes its potency.
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Monoaryl-Substituted Salicylaldoximes as Ligands for Estrogen Receptor β
Filippo Minutolo,Rosalba Bellini,Simone Bertini,Isabella Carboni,Annalina Lapucci,Letizia Pistolesi,G. Prota,Simona Rapposelli,Francesca Solati,Tiziano Tuccinardi,Adriano Martinelli,Fabio Stossi,Kathryn E. Carlson,Benita S. Katzenellenbogen,John A. Katzenellenbogen,Marco Macchia +15 more
TL;DR: The chloro-substituted derivative showed the highest beta affinity and selectivity, and it also proved to be an ERbeta partial agonist with an EC 50 of 11 nM, in good agreement with the results of computational docking analysis.
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Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells.
Jian Min,Valeria Sanabria Guillen,Abhishek Sharma,Abhishek Sharma,Yuechao Zhao,Yvonne S. Ziegler,Ping Gong,Christopher G. Mayne,Sathish Srinivasan,Sung Hoon Kim,Kathryn E. Carlson,Kendall W. Nettles,Benita S. Katzenellenbogen,John A. Katzenellenbogen +13 more
TL;DR: This study has produced structurally novel antiestrogens based on a simple adamantyl core structure with acrylate side chains optimized for cellular antagonist activity that was as efficacious as fulvestrant in suppressing cell proliferation and gene expression.