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Benita S. Katzenellenbogen
Researcher at University of Illinois at Urbana–Champaign
Publications - 403
Citations - 41240
Benita S. Katzenellenbogen is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Estrogen receptor & Estrogen. The author has an hindex of 113, co-authored 394 publications receiving 39585 citations. Previous affiliations of Benita S. Katzenellenbogen include Dartmouth College & University of Cincinnati.
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Estrogen down-regulation of the corepressor N-CoR: Mechanism and implications for estrogen derepression of N-CoR-regulated genes
TL;DR: The findings reveal that, although estrogen directly regulates the transcription of many genes, by regulating a gene such as Siah2 it can exert profound "secondary" effects on cellular activity through mechanisms such as targeting regulatory proteins for degradation.
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Characterization of the estrogen receptor and its dynamics in MCF-7 human breast cancer cells using a covalently attaching antiestrogen
Frederick J. Monsma,Benita S. Katzenellenbogen,Margaret Ann Miller,Yvonne S. Ziegler,John A. Katzenellenbogen +4 more
TL;DR: The findings of similar mol wt and isoelectric points for soluble cytosol and nuclear extracted receptors under strongly denaturing and disaggregating conditions reveal that nuclear localization of receptor after ligand binding is not associated with major structural alterations in the receptor component labeled by TA.
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Anti-estrogen interaction with uterine estrogen receptors. Studies with a radiolabeled anti-estrogen (CI-628).
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Mechanistic Aspects of Estrogen Receptor Activation Probed with Constitutively Active Estrogen Receptors: Correlations with DNA and Coregulator Interactions and Receptor Conformational Changes
TL;DR: The ER undergoes major changes in its conformation and also in its functional properties when it is turned from an inactive into an active state and that mutational changes in the ER protein that result in constitutive, hormone-independent activation mimic many of the changes in ER properties that are normally under hormone regulation.
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A comparative study of antiestrogen action: temporal patterns of antagonism of estrogen stimulated uterine growth and effects on estrogen receptor levels.
TL;DR: Comparative studies with five well-known antiestrogens indicate that they are effective as estrogen antagonists only so long as they maintain cytoplasmic receptor levels low, and that the magnitude of the responsiveness to estradiol after antiestrogen correlates with the extent of reappearance of cy toplasmi receptor.