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Benita S. Katzenellenbogen

Researcher at University of Illinois at Urbana–Champaign

Publications -  403
Citations -  41240

Benita S. Katzenellenbogen is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Estrogen receptor & Estrogen. The author has an hindex of 113, co-authored 394 publications receiving 39585 citations. Previous affiliations of Benita S. Katzenellenbogen include Dartmouth College & University of Cincinnati.

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Estrogen receptor regulation of quinone reductase in breast cancer: implications for estrogen-induced breast tumor growth and therapeutic uses of tamoxifen.

TL;DR: The activation of NQO1 may contribute to the beneficial anticancer and antioxidant activity of antiestrogens in breast cancer and possibly other estrogen target tissues and an important role of the ER in pathways regulating antioxidant defenses is supported.
Journal Article

The stability of the uterine estrogen receptor when complexed with estrogens or antiestrogens.

TL;DR: Ligand-mediated thermal stability and resistance to trypsin-mediated proteolysis were observed to be closely related to binding affinity for receptor and not to whether the ligand was an agonist or antagonist.
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Estrogen receptors of human endometrium: characterization of nuclear and cytoplasmic forms and comparisons with rat uterine receptors

TL;DR: The efficient solubilization of nuclear estrogen receptor by the mild trypsinization method described here should provide a technique useful in analyzing the molecular, properties of estrogen receptors from normal and neoplastic estrogen target tissues.
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Estrogenic potency, receptor interactions, and metabolism of catechol estrogens in the immature rat uterus in vitro.

TL;DR: The catechol estrogens were able to stimulate IP synthesis maximally in immature rat uteri incubated in vitro and the rank order of their potency in stimulating IP synthesis paralleled their relative binding affinity for the receptor.
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Plasminogen activators in human breast cancer cell lines: hormonal regulation and properties.

TL;DR: Dose-response curves for the stimulation of MCF-7 PA activity by different estrogens showed an excellent correlation between affinities of the estrogens for ER and their potency in stimulating PA activity, indicating that the active sites of the PAs were involved in the formation of these complexes.