David J. Robbins

TL;DR: A simple modification of PCR amplification to enhance the production of mutant clones, the majority of which carry only a single base substitution in a specific target DNA sequence, which is time-efficient, cost-effective and relatively effortless when compared to other random mutagenesis methods.

TL;DR: The identification of the human homologue of the Saccharomyces cerevisiae MSH5 is described, which is known to participate in meiotic segregation fidelity and crossing-over and interacts specifically with hMSH4, confirming the generality of functional heterodimeric interactions in the eukaryotic MutS homologue.

TL;DR: It is suggested that BET protein modulation may be an attractive therapeutic strategy for attenuating the growth of HH-dependent cancers, such as medulloblastoma.

TL;DR: The potential for arsenic, even at levels commonly experienced in a U.S. population, to have effects on the DNA methylation status of specific genes in the placenta is demonstrated and thus supports a potentially novel mechanism for arsenic to affect long-term children’s health.

TL;DR: Evidence is provided that relatively low-level arsenic exposure in utero may alter the fetal immune system and lead to immune dysregulation.